Cistrome Cancer: A Web Resource for Integrative Gene Regulation Modeling in Cancer

Cancer Research
Shenglin MeiX Shirley Liu

Abstract

Cancer results from a breakdown of normal gene expression control, so the study of gene regulation is critical to cancer research. To gain insight into the transcriptional and epigenetic factors regulating abnormal gene expression patterns in cancers, we developed the Cistrome Cancer web resource (http://cistrome.org/CistromeCancer/). We conducted the systematic integration and modeling of over 10,000 tumor molecular profiles from The Cancer Genome Atlas (TCGA) with over 23,000 ChIP-seq and chromatin accessibility profiles from our Cistrome collection. The results include reconstruction of functional enhancer profiles, "super-enhancer" target genes, as well as predictions of active transcription factors and their target genes for each TCGA cancer type. Cistrome Cancer reveals novel insights from integrative analyses combining chromatin profiles with tumor molecular profiles and will be a useful resource to the cancer gene regulation community. Cancer Res; 77(21); e19-22. ©2017 AACR.

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Citations

Nov 22, 2018·Nucleic Acids Research·Rongbin ZhengX Shirley Liu
Jul 18, 2019·Cancer Biotherapy & Radiopharmaceuticals·Shradha Mukherjee
Oct 12, 2018·BMC Cancer·Kasey JividenBryce M Paschal
Jun 9, 2020·Frontiers in Genetics·Han ZhangLi Zhang
Sep 22, 2020·BioMed Research International·Yuan-Lin SunYue-Chao Xu
Oct 31, 2018·High-throughput·Maria Eugenia Gallo CantafioMaria Teresa Di Martino
Feb 13, 2020·Journal of Translational Medicine·Zheng WangLixian Ma
Sep 26, 2020·Frontiers in Genetics·Xiong GuoZiwei Wang
Sep 4, 2020·World Journal of Gastrointestinal Oncology·Xiang-Ting QiuJing He
Nov 24, 2020·Frontiers in Cell and Developmental Biology·Ya WangKai Fu
Dec 18, 2020·Frontiers in Molecular Biosciences·Shuting WenFengbin Liu
Dec 4, 2020·The Journal of Steroid Biochemistry and Molecular Biology·Xiaoqiang WangShiuan Chen
Jan 21, 2021·Medicine·Jili Hou, Qiuying Zhong
Aug 11, 2020·International Immunopharmacology·Mengting LiQiu Zhao
Mar 23, 2021·Frontiers in Genetics·Yucheng QianKefeng Ding
Mar 30, 2021·NAR Cancer·Zachary V ThomasChongzhi Zang

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