Citalopram, a selective serotonin reuptake inhibitor augments harmaline-induced tremor in rats

Behavioural Brain Research
Mohammed ArshaduddinM Tariq

Abstract

Citalopram, a serotonin reuptake inhibitor (SSRI) is one of the widely used antidepressants. Apart from its antidepressant activity citalopram is also used for anxiety, panic disorders, obsessive-compulsive disorder and behavioral disturbances of dementia. Tremor is the second most common neurological adverse effect in patients receiving treatment with SSRIs. Use of these agents in depressed patients with essential tremor has not been studied. The present study was undertaken to investigate the effect of chronic citalopram treatment on harmaline-induced tremors in rats. Female Sprague-Dawley rats weighing 70+/-2 g were given citalopram in doses of 0, 10, 20 and 40 mg/kg by gavage for 2 weeks. On the 15th day, the rats were given harmaline (10 mg/kg, i.p.) 30 min after the last dose of citalopram. The latency of onset, intensity and duration of tremor and EMG were recorded. Serotonin (5HT) and 5-hydroxy indole acetic acid (5HIAA) were measured in brain stem. Citalopram dose dependently exacerbated the duration, intensity and amplitude of EMG of harmaline-induced tremor. A significant decrease in 5HT turnover (5HIAA/5HT ratio) in the brain stem was observed suggesting a possible role of serotoninergic impairment in citalopram-ind...Continue Reading

References

Jan 23, 1976·Brain Research·P M HeadleyA W Duggan
Oct 1, 1975·Canadian Journal of Physiology and Pharmacology·C De Montigny, Y Lamarre
Aug 1, 1968·European Journal of Pharmacology·J Bruinvels, T L Sourkes
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·J W Phillis, P H Wu
Jan 1, 1981·Progress in Neurobiology·J W Phillis, P H Wu
Aug 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·P N LeighC D Marsden
Jan 1, 1982·Journal of Neural Transmission·V GloverM Sandler
Jun 1, 1994·The Journal of Pharmacy and Pharmacology·J Mally, T W Stone
Jan 1, 1993·Journal of the Neurological Sciences·M Hallett, R M Dubinsky
Jan 1, 1993·Brain Research Bulletin·R A BarracoH J Normile
Mar 1, 1996·Trends in Pharmacological Sciences·K A JacobsonB B Fredholm
Jan 1, 1997·European Archives of Psychiatry and Clinical Neuroscience·S E HiltonH J Möller
Jan 1, 1996·Pharmacology & Therapeutics·J Mally, T W Stone
Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·E D LouisW A Hauser
Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·N BiaryM Tariq
Nov 9, 2000·European Journal of Pharmacology·K SuemaruY Gomita
Nov 18, 2000·Journal of Neurology·G DeuschlP Krack
May 5, 2001·Expert Opinion on Pharmacotherapy·B G Pollock
Jun 21, 2001·Naunyn-Schmiedeberg's Archives of Pharmacology·K Gołembiowska, A Dziubina
Jul 12, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M J MuñozA Nácher
Jun 12, 2009·Current Neurology and Neuroscience Reports·Rodger J Elble, Günther Deuschl

❮ Previous
Next ❯

Citations

Feb 1, 2011·The Cerebellum·Wacław KolasiewiczKrystyna Ossowska
Feb 28, 2006·Epilepsia·Eduard BercoviciO Carter Snead
Sep 3, 2014·Pharmacology, Biochemistry, and Behavior·Mohammad NasehiMohammad-Reza Zarrindast
Sep 15, 2012·European Journal of Pharmacology·Fatemeh Rahimi ShourmastiAfsaneh Goudarzi
May 19, 2012·Parkinsonism & Related Disorders·A GironellJ D Gispert
Jul 1, 2008·European Journal of Pharmacology·Thomas StöhrJoachim Freitag
Oct 27, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·William G Ondo, Dejian Lai
Aug 30, 2005·Journal of Pharmacological and Toxicological Methods·Sándor FarkasIstván Tarnawa
Oct 27, 2015·The Cerebellum·Juan Marin-Lahoz, Alexandre Gironell
Jul 28, 2016·Neuroscience Research·Yasuha IkawaTomio Inoue
May 17, 2005·Pharmacology, Biochemistry, and Behavior·Mohammed ArshaduddinMohammad Tariq
Jan 18, 2017·Neurological Research·Al Asmari AbdulrahmanMohammed Arshaduddin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.