Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice

BioMed Research International
Zhang WeiQi Jinshun

Abstract

Alzheimer's disease (AD) is the primary cause of dementia. There is no effective treatment. Amyloid-β peptide (Aβ) plays an important role in the pathogenesis and thus strategies suppressing Aβ production and accumulation seem promising. Citalopram is an antidepressant drug and can decrease Aβ production and amyloid plaques in transgenic mice of AD and humans. Whether citalopram can ameliorate memory deficit was not known yet. We tested the effects of citalopram on behavioral performance and synaptic plasticity in female 3xTgAD mice, a well-characterized model of AD. Mice were treated with citalopram or water from 5 months of age for 3 months. Citalopram treatment at approximately 10 mg/kg/day significantly improved spatial memory in the Morris water maze (MWM) test, while not affecting anxiety-like and depression-like behavior in 3xTgAD mice. Further, hippocampal long-term potentiation (LTP) impairment in 3xTgAD mice was reversed by citalopram treatment. Citalopram treatment also significantly decreased the levels of insoluble Aβ40 in hippocampal and cortical tissues in 3xTgAD mice, accompanied with a reduced amyloid precursor protein (APP). Together, citalopram treatment may be a promising strategy for AD and further clinical...Continue Reading

References

Dec 1, 1990·Journal of Neuroscience Research·K J ReinikainenP J Riekkinen
Nov 1, 1985·British Journal of Pharmacology·S E File, S Pellow
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Feb 9, 2000·The Journal of Clinical Psychiatry·J P Feighner, K Overø
Oct 26, 2002·Science·Dennis J Selkoe
Feb 3, 2004·Current Pharmaceutical Design·Wieland GsellPeter Riederer
Aug 6, 2004·Nature·Mark P Mattson
Mar 16, 2005·Archives of Neurology·Zhen-Xin ZhangHui Li
May 3, 2006·Archives of General Psychiatry·Raymond L OwnbyDavid Loewenstein
Jun 7, 2007·Nature Reviews. Neuroscience·Frank M LaFerlaSalvatore Oddo
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Jan 28, 2009·Behavioral Neuroscience·Susanna PietropaoloBenjamin K Yee
Aug 25, 2009·Pharmacology, Biochemistry, and Behavior·Bethany R Brookshire, Sara R Jones
Oct 20, 2009·European Journal of Pharmacology·Annerieke S R SierksmaJos Prickaerts
Sep 18, 2010·International Journal of Geriatric Psychiatry·Robert HowardRichard Gray
Apr 8, 2011·Science Translational Medicine·David M HoltzmanAlison M Goate
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·John R CirritoYvette I Sheline
May 1, 2012·Journal of Alzheimer's Disease : JAD·Michel BenoitPhilippe Robert
Dec 12, 2012·Neuropharmacology·Darrick T BaluIrwin Lucki
Mar 12, 2013·Neurobiology of Aging·Ina TesseurBart De Strooper
Feb 20, 2014·JAMA : the Journal of the American Medical Association·Anton P PorsteinssonUNKNOWN CitAD Research Group
May 16, 2014·Science Translational Medicine·Yvette I ShelineJohn R Cirrito
May 30, 2014·Journal of Neural Transmission·Boris MlinarRenato Corradetti
Jan 23, 2015·The International Journal of Neuropsychopharmacology·Adele RomanoTommaso Cassano
Jun 16, 2015·Frontiers in Cellular Neuroscience·Sergio T FerreiraFernanda G De Felice
Jun 16, 2015·Frontiers in Aging Neuroscience·Marcus O W GrimmTobias Hartmann
Apr 2, 2016·The American Journal of Psychiatry·Anne K LeonpacherUNKNOWN CitAD Research Group
Apr 5, 2016·Current Alzheimer Research·R Pardossi-PiquardChecler F

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Citations

May 21, 2020·Translational Psychiatry·Forugh S Dafsari, Frank Jessen
Sep 20, 2019·Neural Regeneration Research·Bernadette MdawarRita Khoury

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Methods Mentioned

BETA
ELISA
electrophoresis
transgenic

Software Mentioned

SMART
ImageJ
SPSS
sigmaplot
Ethovision

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