Citalopram and sertraline exposure compromises embryonic bone development

Molecular Psychiatry
D FraherY Gibert

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed treatments for depression and, as a class of drugs, are among the most used medications in the world. Concern regarding possible effects of SSRI treatment on fetal development has arisen recently as studies have suggested a link between maternal SSRI use and an increase in birth defects such as persistent pulmonary hypertension, seizures and craniosynostosis. Furthermore, SSRI exposure in adults is associated with decreased bone mineral density and increased fracture risk, and serotonin receptors are expressed in human osteoblasts and osteoclasts. To determine possible effects of SSRI exposure on developing bone, we treated both zebrafish, during embryonic development, and human mesenchymal stem cells (MSCs), during differentiation into osteoblasts, with the two most prescribed SSRIs, citalopram and sertraline. SSRI treatment in zebrafish decreased bone mineralization, visualized by alizarin red staining and decreased the expression of mature osteoblast-specific markers during embryogenesis. Furthermore, we showed that this inhibition was not associated with increased apoptosis. In differentiating human MSCs, we observed a decrease in osteoblast ac...Continue Reading

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Oct 26, 2018·Fundamental & Clinical Pharmacology·Marzieh KhademiZahra Taghipour
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Apr 12, 2021·Molecular and Cellular Endocrinology·Daniel FraherYann Gibert
Dec 3, 2021·Environmental Science & Technology·Sophie L GouldCharles R Tyler

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