Citalopram treatment of depression in Parkinson's disease: the impact on anxiety, disability, and cognition

The Journal of Neuropsychiatry and Clinical Neurosciences
M A MenzaMarc Lauritano

Abstract

Depression in Parkinson's disease (PD) is associated with faster progression of physical symptoms, greater decline in cognitive skills, and greater decline in the ability to care for oneself. The depression in these patients is also frequently comorbid with anxiety. There are no trials that provide data on the impact of depression treatment on anxiety, disability, and cognition in these patients. In this prospective, 8-week, open label trial, 10 patients with PD and major depression, without dementia, were given flexible doses of citalopram. Depression improved significantly and was associated with significant improvements in anxiety symptoms and functional impairment. The drug was well tolerated. This is the first study that provides data suggesting that treating depression in patients with PD may lead to improvements in anxiety and functional capacity. As with all nonrandomized, open-label trials at tertiary research centers, many nonspecific factors may have influenced the results.

Associated Clinical Trials

Jan 2, 2006·Jess G. Fiedorowicz, Jess G. Fiedorowicz

Citations

Jul 3, 2013·Experimental Brain Research·Philippe Huot, Susan H Fox
Aug 16, 2005·Current Psychiatry Reports·Jacqueline E MullerDan J Stein
Apr 28, 2006·Current Opinion in Psychiatry·Uwe Ehrt, Dag Aarsland
Apr 14, 2006·Current Opinion in Psychiatry·Hugh Rickards
Sep 12, 2006·The Journal of Neuropsychiatry and Clinical Neurosciences·Daniel WeintraubMatthew B Stern
Apr 9, 2011·International Journal of General Medicine·Marty HinzThomas Uncini
Feb 18, 2014·Current Treatment Options in Neurology·Atbin Djamshidian, Joseph H Friedman
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Gregory M PontoneLaura Marsh
Nov 8, 2008·Annals of the New York Academy of Sciences·Shen-Yang LimJanis M Miyasaki
Apr 26, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Angelo AntoniniGianni Pezzoli
Mar 19, 2011·Annals of Neurology·Valerie VoonMark Stacy
Jan 1, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Leigh J BeglingerJane S Paulsen
Mar 24, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·E PeñaUNKNOWN en nombre del grupo de trastornos del movimiento de la Asociación Madrileña de Neurología
Aug 19, 2015·International Journal of Geriatric Psychiatry·Gregory M PontoneSusan S Bassett
Jun 27, 2006·Journal of the Neurological Sciences·Anette Schrag
Sep 10, 2005·Clinical Neurology and Neurosurgery·Spiridon PapapetropoulosNicoletta P Lekka
Jun 15, 2007·Expert Review of Neurotherapeutics·Leora L BorekJoseph H Friedman
Aug 31, 2006·Expert Opinion on Emerging Drugs·John C Morgan, Kapil D Sethi
Mar 27, 2015·Parkinson's Disease·Philippe HuotJonathan M Brotchie
Jul 20, 2005·Journal of Clinical Psychopharmacology·K Ranga Rama Krishnan
Oct 20, 2009·Arquivos de neuro-psiquiatria·Arthur Kummer, Antonio Lucio Teixeira
Jul 4, 2006·CNS Spectrums·Leora L BorekJoseph H Friedman
Apr 30, 2017·Clinical Gerontologist·Nadeeka N W DissanayakaNancy A Pachana
Mar 20, 2013·Journal of Psychiatric Practice·Rosa Quelhas
Jan 11, 2014·Therapeutic Advances in Neurological Disorders·Jack J Chen, Laura Marsh
Nov 24, 2016·Journal of Neural Transmission·Rastislav ŠumecMartin Bareš
Jun 27, 2019·Expert Review of Neurotherapeutics·Isabella BerardelliGiovanni Fabbrini
Jul 12, 2019·The Mental Health Clinician·Jamie L McCarrellAmie Taggart Blaszczyk
Sep 28, 2017·Current Treatment Options in Psychiatry·Elizabeth A CroccoKatherine Camfield
Apr 4, 2020·Journal of Geriatric Psychiatry and Neurology·Amitha DhingraAdriana P Hermida

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