Citicoline enhances neuroregenerative processes after experimental stroke in rats

Stroke; a Journal of Cerebral Circulation
Kai DiederichWolf-Rüdiger Schäbitz

Abstract

The neuroprotective potential of citicoline in acute ischemic stroke has been shown in many experimental studies and, although the exact mechanisms are still unknown, a clinical Phase III trial is currently underway. Our present study was designed to check whether citicoline also enhances neuroregeneration after experimental stroke. Forty Wistar rats were subjected to photothrombotic stroke and treated either with daily injections of citicoline (100 mg/kg) or vehicle for 10 consecutive days starting 24 hours after ischemia induction. Sensorimotor tests were performed after an adequate training period at Days 1, 10, 21, and 28 after stroke. Then brains were removed and analyzed for infarct size, glial scar formation, neurogenesis, and ligand binding densities of excitatory and inhibitory neurotransmitter receptors. Animals treated with citicoline showed a significantly better neurological outcome at Days 10, 21, and 28 after ischemia, which could not be attributed to differences in infarct volumes or glial scar formation. However, neurogenesis in the dentate gyrus, subventricular zone, and peri-infarct area was significantly increased by citicoline. Furthermore, enhanced neurological outcome after citicoline treatment was associ...Continue Reading

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Citations

Apr 17, 2014·International Journal of Molecular Sciences·Andrea MatteucciFiorella Malchiodi-Albedi
Dec 23, 2015·Expert Review of Neurotherapeutics·Antje Schmidt, Jens Minnerup
Apr 23, 2013·Journal of Neurochemistry·Olivia HurtadoIgnacio Lizasoain
Mar 22, 2016·International Journal of Molecular Sciences·Jose Alvarez-SabínManuel Quintana
Sep 10, 2014·Pharmacology & Therapeutics·Antonio MorettiRoberto F Villa
Feb 9, 2013·Neurorehabilitation and Neural Repair·Michael P Kahle, Gregory J Bix
May 15, 2016·Toxicology and Industrial Health·Ahmed O Abdel-ZaherDoaa H Abd El-Hamid
Jul 17, 2015·Journal of Attention Disorders·Erin McGladeDeborah Yurgelun-Todd
Sep 8, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ligen ShiJun Chen
Oct 30, 2013·Antimicrobial Agents and Chemotherapy·Fatima El-AssaadRonan Jambou
Dec 6, 2012·Stroke; a Journal of Cerebral Circulation·Carlos MatuteBruce R Ransom
Aug 22, 2018·International Journal of Molecular Sciences·Patricia BogdanovCristina Hernández
Nov 23, 2017·Oxidative Medicine and Cellular Longevity·Sergio DavinelliGiovanni Scapagnini
Jan 1, 2013·Brain Sciences·José Alvarez-Sabín, Gustavo C Román
Jun 3, 2021·International Journal of Molecular Sciences·Nguyen Khanh Toan, Sang-Gun Ahn

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