DOI: https://doi.org/10.51161/rems/957Apr 23, 2021Proceedings Paper

CITOCINAS E MORBIDADE CARDÍACA NA DOENÇA DE CHAGAS

Kéven Martins WragueGabriela Vasconcelos De Moura

Abstract

INTRODUÇÃO: A Organização Mundial de Saúde (OMS) estima que cerca de 8 milhões de pessoas no mundo apresentam a doença de chagas, sendo que dessas cerca de 20 a 40% desenvolvem algum dano cardíaco. A cardiomiopatia chagásica crônica (CCC) é uma cardiomiopatia inflamatória dilatada que apresenta um prognóstico negativo devido a elevada expressão de citocinas inflamatórias. A morbimortalidade na doença de chagas segue elevada devido a negligência, pois 20% dos infectados não têm acesso ao diagnóstico e tratamento da doença devido a estigmas e sintomatologia silenciosa, o que facilita o surgimento das sequelas. OBJETIVO: Analisar prevalência de citocinas plasmáticas e sua influência na morbimortalidade de pacientes com cardiomiopatia chagásica comparada a grupo controle indeterminado MÉTODOS: Foram coletadas informações no banco de dados PubMed e LILCAS, incluindo artigos originais em inglês e português, indexados pelos descritores DECs/MeSH: “Cardiomiopatia”, “Chagas”, “Citocinas”. Ao total, foram considerados 7 artigos, após aplicar o critério de exclusão de estudos clínicos com pequena amostra e publicados há mais de 15 anos, apenas 3 foram selecionados para essa revisão bibliográfica. RESULTADOS: Obteve-se após comparação de d...Continue Reading

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