Citrate anticoagulation for continuous renal replacement therapy in small children

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Jolanta SoltysiakJacek Zachwieja

Abstract

Regional citrate anticoagulation (RCA) is one of the methods used to prevent clotting in continuous renal replacement therapy (CRRT). The aim of this study was to describe the outcomes and complications of RCA-CRRT in comparison to heparin anticoagulation (HA)-CRRT in critically ill children. This study was a retrospective review of 30 critically ill children (16 on RCA- and 14 on HA-CRRT) who underwent at least 24 h of CRRT. The mean body weight of the children was 8.69 ± 5.63 kg. RCA-CRRT was performed with a commercially available pre-dilution citrate solution (Prismocitrate 18/0). The mean time on RCA-CRRT and HA-CRRT was 148.73 ± 131.58 and 110.24 ± 105.38 h, respectively. Circuit lifetime was significantly higher in RCA-CRRT than in HA-CRRT (58.04 ± 51.18 h vs. 37.64 ± 32.51 h, respectively; p = 0.030). Circuit clotting was observed in 11.63 % of children receiving RCA-CRRT and 34.15 % of those receiving HA-CRRT. Episodic electrolyte and metabolic disturbances were more common in children receiving RCA-CRRT. The survival at discharge from the hospital was 37.5 and 14.3 % among children receiving RCA-CRRT and HA-CRRT, respectively. In critically ill children with a low body weight, RCA appeared to be safe and easy to used....Continue Reading

References

Nov 30, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B A Warady, T Bunchman
Apr 17, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Timothy E BunchmanMark R Benfield
Oct 12, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vimal ChadhaUri S Alon
Jan 8, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brahm GoldsteinUNKNOWN International Consensus Conference on Pediatric Sepsis
Apr 30, 2005·Journal of Pediatric Gastroenterology and Nutrition·Way Seah LeeDeirdre Anne Kelly
Oct 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Edith BauerWilfred Druml
Mar 31, 2007·Kidney International·A Akcan-ArikanS L Goldstein
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Ashita J TolwaniKeith M Wille
Feb 7, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Justyna Kozik-JarominJoachim Böhler
Mar 12, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Martin KreuzerLars Pape
Sep 30, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gerd R HetzelLars C Rump
Jan 10, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mei-Yi WuKa-Wai Tam
Mar 1, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Scott M Sutherland, Steven R Alexander
Aug 24, 2012·Critical Care : the Official Journal of the Critical Care Forum·Caroline SchultheißWolfgang Huber
Sep 15, 2012·Korean journal of pediatrics·Young Bae SohnDong-Kyu Jin
Sep 19, 2012·Critical Care : the Official Journal of the Critical Care Forum·Sameer Patel, Julia Wendon
Oct 26, 2012·Blood Purification·Ashita Tolwani, Keith M Wille

❮ Previous
Next ❯

Citations

Feb 3, 2015·Seminars in Pediatric Surgery·Felix C BlancoFaisal G Qureshi
Oct 16, 2015·Revista chilena de pediatría·Felipe Cavagnaro Santa MaríaRicardo Ronco Macchiavello
Jun 18, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Jadranka Buturovic-Ponikvar
Oct 28, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Anna MusielakJacek Zachwieja
Nov 30, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mayerly Prada RicoAna Maria Quintero Gómez
Jul 19, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Tomáš ZaoralEliška Gelnarová
Apr 29, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Gerard CortinaWarwick Butt
Mar 20, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lara de GalassoIsabella Guzzo
Mar 2, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aadil KakajiwalaBenjamin Laskin
Jun 5, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Paulien A M A Raymakers-JanssenJosephus P J van Gestel
Mar 11, 2021·Journal of Intensive Care Medicine·Rupesh RainaAlexander Botsch

❮ Previous
Next ❯

Software Mentioned

CRRT
PrismaSol
HA

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.