Citrate Crosslinked Poly(Glycerol Sebacate) with Tunable Elastomeric Properties.

Macromolecular Bioscience
Brandon B RisleyYadong Wang

Abstract

Poly(glycerol-sebacate) (PGS) is a biodegradable elastomer known for its mechanical properties and biocompatibility for soft tissue engineering. However, harsh thermal crosslinking conditions are needed to make PGS devices. To facilitate the thermal crosslinking, citric acid is explored as a crosslinker to form poly(glycerol sebacate citrate) (PGSC) elastomers. The effects of varying citrate contents and curing times are investigated on the mechanical properties, elasticity, degradation, and hydrophilicity. To examine the potential presence of unreacted citric acid, material acidity is monitored in relation to the citrate content and curing times. It is discovered that a low citrate content and a short curing time produce PGSC with tunable mechanical characteristics similar to PGS with enhanced elasticity. The materials demonstrate good cytocompatibility with human umbilical vein endothelial cells similar to the PGS control. The research study suggests that PGSC is a potential candidate for large-scale biomedical applications because of the quick thermal crosslink and tunable elastomeric properties.

References

Jun 4, 2002·Nature Biotechnology·Yadong WangRobert Langer
Jul 2, 2003·Journal of Biomedical Materials Research. Part a·Yadong WangRobert Langer
Oct 1, 2003·Journal of Biomedical Materials Research. Part a·Steven P HigginsLaura E Niklason
Nov 18, 2005·Biomaterials·Jian YangGuillermo A Ameer
Aug 30, 2007·Biomacromolecules·Christiaan L E NijstRobert Langer
Dec 25, 2008·Journal of Biomedical Materials Research. Part a·Irina PomerantsevaCathryn A Sundback
Oct 30, 2009·International Journal of Molecular Sciences·SuPing Lyu, Darrel Untereker
Jan 22, 2010·Journal of Biomedical Materials Research. Part a·Jessica M Kemppainen, Scott J Hollister
Apr 9, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Kara L Menzies, Lyndon Jones
Dec 15, 2012·Advanced Materials·Maria José Nunes PereiraJeffrey M Karp
May 22, 2013·Nature Reviews. Cardiology·Dawit G SeifuDiego Mantovani
Jun 6, 2013·Journal of Biomedical Materials Research. Part a·Jeffrey M HalpernHorst A von Recum
Aug 6, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Ranjana RaiAldo R Boccaccini
Sep 12, 2013·Tissue Engineering. Part a·Samer Helal ZakyCharles Sfeir
Feb 18, 2015·Acta Biomaterialia·Eric M JeffriesYadong Wang
Aug 25, 2015·Acta Biomaterialia·Punyavee Kerativitayanan, Akhilesh K Gaharwar
Oct 8, 2016·Biofabrication·Yi-Cheun YehJason A Burdick
Oct 22, 2016·Biomaterials·Xiaochu DingYadong Wang
Mar 23, 2017·Chemistry Central Journal·Rosaria CiriminnaMario Pagliaro
Dec 26, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaochu DingYadong Wang
Aug 4, 2018·Acta Biomaterialia·Dharaminder SinghFrederik Claeyssens
Jan 20, 2021·ACS Biomaterials Science & Engineering·Xiaochu DingYadong Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.