Citrem modulates internal nanostructure of glyceryl monooleate dispersions and bypasses complement activation: Towards development of safe tunable intravenous lipid nanocarriers

Nanomedicine : Nanotechnology, Biology, and Medicine
Peter Popp WibroeSeyed Moein Moghimi

Abstract

Lyotropic non-lamellar liquid crystalline (LLC) aqueous nanodispersions hold a great promise in drug solubilization and delivery, but these nanosystems often induce severe hemolysis and complement activation, which limit their applications for safe intravenous administration. Here, we engineer and characterize LLC aqueous nanodispersions from a binary lipid mixture consisting of 2,3-dihydroxypropyl oleate (glyceryl monooleate) and medium-chain triglycerides with tunable internal nanostructures and improved hemocompatibility controlled by citrem as stabilizer. Citrem, in a concentration-dependent manner, modulates the internal nanostructure of LLC dispersions from a biphasic H2/L2 feature to a neat L2 phase, where the latter resembles "thread-like" swollen micelles. Citrem stabilization totally overcomes hemolysis and complement activation, thus realizing the potential of the engineered LLC aqueous nanodispersions for exploitation in intravenous delivery of drugs and contrast agents. The complement system often gets activated after intravenous injection of nano drug-carriers. This may result in detrimental systemic effects. The authors described in this article the use of citrem as a stabilizing agent and showed the ability of t...Continue Reading

References

Jan 12, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Anan YaghmurOtto Glatter
Jan 27, 2005·Journal of the American Chemical Society·Markus JohnssonFredrik Tiberg
Sep 23, 2008·Advances in Colloid and Interface Science·Anan Yaghmur, Otto Glatter
Jun 22, 2011·Advanced Drug Delivery Reviews·S Moein MoghimiA Christy Hunter
Jul 13, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shoshy MizrahyDan Peer
Jul 27, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Christa NilssonAnan Yaghmur
Mar 19, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·S Moein Moghimi, Z Shadi Farhangrazi
Jun 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Islam HamadS Moein Moghimi
Feb 24, 2015·Frontiers in Immunology·Alex Langford-SmithSimon J Clark
Apr 18, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Intan Diana Mat AzmiAnan Yaghmur

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Citations

Dec 15, 2015·Therapeutic Delivery·Intan D M AzmiAnan Yaghmur
Apr 14, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wesam R KadhumKenji Sugibayashi
Aug 16, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Intan D M AzmiAnan Yaghmur
Feb 14, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Jiali ZhaiCalum J Drummond
Jun 6, 2019·Physical Chemistry Chemical Physics : PCCP·Anan YaghmurWinnie Edith Svendsen
Jun 22, 2019·Advanced Materials·Raffaele MezzengaLaurent Sagalowicz
Apr 4, 2019·The Journal of Pharmacology and Experimental Therapeutics·S Moein MoghimiA Christy Hunter
Dec 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anan YaghmurSeyed Moein Moghimi
Sep 5, 2020·Expert Opinion on Drug Delivery·Ana Vitoria Pupo SilvestriniMaria Vitoria Lopes Badra Bentley
Aug 28, 2020·Nanomaterials·Bwalya A WitikaRoderick B Walker
Dec 24, 2019·Frontiers in Bioengineering and Biotechnology·Anan YaghmurStefan Salentinig
Jan 27, 2019·Therapeutic Delivery·Gizem BorAnan Yaghmur
May 12, 2020·Advanced Drug Delivery Reviews·S Moein MoghimiZ Shadi Farhangrazi
May 18, 2021·Acta Pharmaceutica Sinica. B·Anan Yaghmur, Huiling Mu
Nov 15, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Anan YaghmurStefan Salentinig
Oct 24, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Amin SadeghpourChandrashekhar V Kulkarni
Apr 8, 2020·Nano Letters·Martina PannuzzoPaolo Decuzzi
Feb 27, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Carlos M Baez-CottoMahesh K Mahanthappa

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