Abstract
Event-related potential (ERP) is a reliable neuroelectric measure of brain activity that helps to confirm the assessment of mental status and cognitive impairment. Many studies have reported that alcoholics show a significantly lower ERP P300 amplitude than the norm. In the present study, ERP P300 waves were measured to evaluate the effect of citric acid on cognitive function during excessive alcohol consumption in healthy adults. Five volunteers were selected through clinical interview, physical examination, and psychiatric assessment for participation in this study. In a double-blind placebo-controlled before-after design, each subject was treated with 5 ml/kg body weight alcohol, 5 ml/kg body weight alcohol and 1 mg citric acid, or a placebo on three separate occasions, one week apart. ERP P300, blood biochemical indicators, blood alcohol concentrations (BACs) and acetaldehyde concentrations were assessed. Repeated measure analysis of variance (ANOVA) with a within-subjects factor was used to evaluate differences in blood biochemical indicators, BACs, blood acetaldehyde concentrations, and ERP P300 in the three sessions of assessments. Several blood biochemical indicators showed significant differences between treatments, in...Continue Reading
References
May 1, 1990·Electroencephalography and Clinical Neurophysiology·J PolichF E Bloom
Aug 19, 1991·The Medical Journal of Australia·R R Tuck, M Jackson
Apr 1, 1987·Electroencephalography and Clinical Neurophysiology·G BarrettH Shibasaki
Apr 24, 1987·Science·C R Cloninger
Jun 1, 1988·Biological Psychology·A W Gaillard
Jul 1, 1987·Alcohol·M Oscar-Berman
Jul 1, 1987·Alcohol·A PfefferbaumJ M Ford
May 1, 1980·Psychophysiology·J B IsrealE Donchin
Dec 1, 1993·The Japanese Journal of Psychiatry and Neurology·Y Miyazato, C Ogura
May 1, 1993·Brain and Cognition·S C Bowden, R J McCarter
Aug 15, 1996·Biological Psychiatry·I P JääskeläinenP Sillanaukee
May 30, 2001·Drug and Alcohol Dependence·A Liguori, J H Robinson
Aug 29, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·H F MoselhyA Kahn
Dec 18, 2001·Journal of Neuroscience Research·L L FonsecaH Santos
Oct 24, 2003·Brain and Cognition·Frances Heritage Martin, David A T Siddle
Mar 28, 2006·Human Psychopharmacology·Hee-Young ShinJin-Sang Yoon
Nov 17, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Shunsuke Meshitsuka, David A Aremu
Apr 11, 2008·Pediatrics·Robert A ZuckerHoward B Moss
Jul 1, 2008·Psychopharmacology·M CorreaC M G Aragon
Oct 11, 2008·Free Radical Biology & Medicine·James HaorahYuri Persidsky
Jan 17, 2009·Life Sciences·Mercè CorreaJohn D Salamone
Feb 6, 2010·Biological Psychiatry·Andrea CippitelliMarkus Heilig
Mar 23, 2010·Journal of Psychopharmacology·Anne E WesterJ Leon Kenemans
May 18, 2010·Brain Research·Xiaoyi LiHuadong Zhou
Aug 10, 2011·Neuroscience and Biobehavioral Reviews·Mercè CorreaElio Acquas