Citrinin against breast cancer: A cytogenotoxicological study.

Phytotherapy Research : PTR
José Williams Gomes de Oliveira FilhoAna Amélia de Carvalho Melo Cavalcante

Abstract

Breast cancer is one of the most lethal types of cancer and a leading cause of mortality among Women worldwide. Citrinin (CIT), a polyketide extracted from the fungus Penicillium citrinum, exhibits a wide range of biological activities such as antibacterial, antifungal, and cytotoxic effects. The aim of the current study was to evaluate the antitumoral effects of CIT against 7,12-dimethylbenzanthracene (DMBA)-induced mammary carcinoma in Swiss mice For this, CIT, DMBA and the standard cyclophosphamide (CPA) induced behavioral changes in experimental animals, and these changes were screened by using the rota rod and open field tests. Additionally, hematological, biochemical, immuno-histochemical, and histopathological analyses were carried out. Results suggest that CIT did not alter behavioral, hematological, and biochemical parameters in mice. DMBA induced invasive mammary carcinoma and showed genotoxic effects in the breasts, bone marrow, lymphocytes, and hepatic cells. It also caused mutagenic effects in the formation of micronuclei, bridges, shoots, and binucleate cells in bone marrow and liver. CIT and CPA genotoxic effects were observed after 3 weeks of therapy, where CIT exhibited a repair capacity and induced significant...Continue Reading

References

Dec 1, 1977·Food and Cosmetics Toxicology·G A Sansing
Feb 1, 1977·Food and Cosmetics Toxicology·W H JordonG A Sansing
Jun 11, 2002·International Journal of Toxicology·M MirshahiM K Agarwal
Nov 3, 2005·Toxicologic Pathology·Nicolas CurrierDavid C Seldin
Apr 14, 2009·Toxicology and Applied Pharmacology·Chia-Hao ChangBiing-Hui Liu
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Dubravka Flajs, Maja Peraica
Jul 10, 2012·Toxicology and Industrial Health·Manoj KumarNittin Dev Singh
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Carol DeSantisAhmedin Jemal
May 17, 2014·Phytotherapy Research : PTR·Jean-François LesgardsSylvia Pietri
Oct 4, 2014·Molecular and Clinical Oncology·Reiki NishimuraNobuyuki Arima
Oct 21, 2014·PloS One·Aliny Pereira LimaElisângela de Paula Silveira-Lacerda
May 9, 2015·Journal of Clinical and Diagnostic Research : JCDR·Vidya GunasekaranaParkash Chand
Jun 27, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Loganathan GayathriMohammad A Akbarsha
Jan 27, 2016·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Robin SabharwalShivangi Gupta
Mar 28, 2016·The Breast : Official Journal of the European Society of Mastology·Juan Ignacio ArrarasMiguel Angel Dominguez
May 24, 2016·Marine Drugs·Nelson G M GomesAlexander Kornienko
Oct 30, 2016·European Journal of Medical Genetics·Darko GrujičićOlivera Milošević-Djordjević
Jan 4, 2017·Chemical Biology & Drug Design·Maryam Majidinia, Bahman Yousefi
Feb 15, 2017·BBA Clinical·Kiven Erique Lukong
Aug 16, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Meilan XueLichen Zhang
Sep 21, 2017·Behavioural Brain Research·Jessica K CaoNephi Stella
Oct 11, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·José Williams Gomes de Oliveira FilhoAna Amélia de Carvalho Melo-Cavalcante
Nov 6, 2018·IUBMB Life·Marcus Vinícius Oliveira Barros de AlencarAna Amélia de Carvalho Melo-Cavalcante
Oct 1, 2019·Environmental and Molecular Mutagenesis·Derek T BernackiStephanie L Smith-Roe
Dec 8, 2019·International Journal of Molecular Sciences·Mahsa KarbaschiMarcus S Cooke

Related Concepts

Metazoa
Antineoplastic Agents
Citrinin
Cyclophosphamide Monohydrate
Genotoxic Stress
Females
Mutagens
Neoplasms, Experimental
Penicillium
9,10-Dimethyl-1,2-benzanthracene

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