PMID: 3727311May 1, 1986

Citrinin mycotoxicosis in the rabbit: ultrastructural alterations

Veterinary Pathology
C HanikaJ Tuite

Abstract

Citrinin was given to rabbits as a single oral dose of 120 or 67 mg/kg. Rabbits were killed at 4, 6, 8, 10, and 12 hours post dosing, and the kidneys were fixed by intravascular perfusion. Ultrastructural alterations were evident by 4 hours after treatment. In the proximal tubule, alterations were brush border disruption, cytoplasmic rarefaction, and swelling of interdigitating processes. At higher doses, mitochondria were condensed and distorted. Medullary and straight cortical distal tubules had marked distention of the intercellular spaces and disorganization of interdigitating processes. Changes in cortical and outer medullary collecting ducts were similar but less severe. Renal alterations were suggestive of damage to membrane structure and/or transport functions and interference with cellular bioenergetics. Leukocytic infiltration was associated with damaged tubules indicating a contribution of inflammation to the development of the lesions.

References

Dec 1, 1977·Food and Cosmetics Toxicology·G Sansing
Aug 1, 1978·Food and Cosmetics Toxicology·W H Jordan, W W Carlton
Oct 1, 1978·Food and Cosmetics Toxicology·W H JordanG Sansing
Feb 1, 1977·Food and Cosmetics Toxicology·W H JordonG Sansing
May 1, 1977·Veterinary Pathology·D N KitchenJ Tuite
Jul 1, 1970·The Journal of Infectious Diseases·F SilverblattR Bulger
Aug 1, 1974·Food and Cosmetics Toxicology·W W CarltonJ Tuite
Oct 1, 1969·The American Journal of Physiology·B M TuneC S Patlak
Dec 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C HanikaJ Tuite
Sep 1, 1983·Archives of Toxicology·W O Berndt
Aug 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C HanikaJ Tuite
Dec 1, 1981·Food and Cosmetics Toxicology·N A MehdiJ Tuite
Jun 1, 1980·Experimental and Molecular Pathology·V G LockardR M O'Neal
Jan 1, 1980·Toxicology·R D PhillipsW L Williams
Jan 1, 1983·Avian Pathology : Journal of the W.V.P.A·N A MehdiJ Tuite
Jan 1, 1984·Avian Pathology : Journal of the W.V.P.A·N A MehdiJ Tuite

Citations

Dec 30, 2006·Molecular Nutrition & Food Research·Annie Pfohl-Leszkowicz, Richard A Manderville
Sep 1, 1992·Zeitschrift für Ernährungswissenschaft·H K Frank

Related Concepts

Benzopyrans
Citrinin
Kidney
Kidney Diseases
Structure of Collecting Tubule
Distal Convoluted Renal Tubule Structure
Kidney Tubules, Proximal
Electron Microscopy
Mycotoxins

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
C HanikaJ Tuite
© 2021 Meta ULC. All rights reserved