PMID: 6542549Dec 1, 1984

Citrinin mycotoxicosis in the rabbit: clinicopathological alterations

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
C HanikaJ Tuite

Abstract

Citrinin, a nephrotoxic mycotoxin, was dissolved in 0.5 N-NaOH neutralized with HCl and given in a single oral dose of 120 mg/kg (Trial I) or 80 or 100 mg/kg (Trial II) to male New Zealand white rabbits weighing 2.0-2.7 kg. In Trial I, sequential measurements of clinicopathological parameters were made over a 24-hr period. Azotaemia and metabolic acidosis with haemoconcentration and hypokalaemia developed within 4-12 hr. In Trial II, clinicopathological and urinary parameters were measured daily for 7 days. Increased blood urea nitrogen and serum-creatine levels and decreased creatinine clearance indicated renal failure; these values were most abnormal on days 2-4, returning to normal or near normal by day 7 in rabbits that survived. Urine analysis indicated tubular dysfunction and necrosis with glucosuria, isosthenuria and cylindruria; most urinary parameters were normal by day 7.

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Citations

Sep 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J A EngelhardtA W Hayes
Nov 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J A EngelhardtA W Hayes
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Dubravka Flajs, Maja Peraica
Dec 30, 2006·Molecular Nutrition & Food Research·Annie Pfohl-Leszkowicz, Richard A Manderville
Aug 1, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ting-Shuan WuBiing-Hui Liu
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May 1, 1986·Veterinary Pathology·C HanikaJ Tuite

Related Concepts

Metazoa
Benzopyrans
Carbonic Acid Ions
Blood Glucose
Serum Proteins
Blood Urea Nitrogen Measurement
Citrinin
Krebiozen
Hematocrit Procedure
Hydrogen-Ion Concentration

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