PMID: 6684630Aug 1, 1983

Citrinin mycotoxicosis in the rabbit

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
C HanikaJ Tuite

Abstract

In three trials, single or multiple doses of citrinin dissolved in 0.5 N-NaOH and adjusted to neutral pH with HCl were given to rabbits by either the oral or intraperitoneal route. The 72-hr LD50 was 50 mg/kg body weight by intraperitoneal administration and 134 mg/kg by the oral route. The primary clinical sign in rabbits receiving a single oral dose of 125-150 mg citrinin/kg was fluid diarrhoea commencing 8 hr after dosing. Pathological alterations were generally confined to the kidney and consisted of degeneration and necrosis of proximal convoluted tubules and straight segments. In rabbits given a single oral dose of citrinin (130 mg/kg) the earliest histopathological change, seen 8 hr after dosing, was cytoplasmic vacuolation of tubular epithelial cells. Rabbits given a single oral dose of 120 mg citrinin/kg had regeneration of renal tubular epithelium accompanied by slight tubular cell necrosis when examined 7 days after dosing. Rabbits given multiple sublethal doses of citrinin (33.5 or 77 mg/kg daily for 7 days) had renal alterations of mild tubular degeneration and necrosis, and tubular regeneration.

References

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Citations

May 1, 1992·Archives of Environmental Contamination and Toxicology·R C BraunbergL Friedman
Mar 1, 1989·Toxicology and Applied Pharmacology·D E MalarkeyP M Newberne
Dec 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C HanikaJ Tuite
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Dubravka Flajs, Maja Peraica
Dec 30, 2006·Molecular Nutrition & Food Research·Annie Pfohl-Leszkowicz, Richard A Manderville
Jul 16, 2010·Journal of Food Science·Chun-Hsien LeeTzu-Ming Pan
Jan 1, 1984·Drug and Chemical Toxicology·J C PiccianoD E Rodwell
Jan 1, 1988·Critical Reviews in Toxicology·G LaurentP Maldague
Sep 13, 2017·Journal of the Science of Food and Agriculture·Nurshad Ali
Aug 30, 2008·Journal of Food Protection·Mitsuru Watanabe
May 1, 1986·Veterinary Pathology·C HanikaJ Tuite
Oct 29, 2020·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Ivana SpevakovaMarcela Capcarova

Related Concepts

Metazoa
Benzopyrans
Citrinin
Dose-Response Relationship, Drug
Kidney
Kidney Tubular Necrosis, Acute
Lethal Dose 50
Mycotoxins
Chinchilla Rabbits

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