PMID: 6684630Aug 1, 1983

Citrinin mycotoxicosis in the rabbit

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
C HanikaJ Tuite


In three trials, single or multiple doses of citrinin dissolved in 0.5 N-NaOH and adjusted to neutral pH with HCl were given to rabbits by either the oral or intraperitoneal route. The 72-hr LD50 was 50 mg/kg body weight by intraperitoneal administration and 134 mg/kg by the oral route. The primary clinical sign in rabbits receiving a single oral dose of 125-150 mg citrinin/kg was fluid diarrhoea commencing 8 hr after dosing. Pathological alterations were generally confined to the kidney and consisted of degeneration and necrosis of proximal convoluted tubules and straight segments. In rabbits given a single oral dose of citrinin (130 mg/kg) the earliest histopathological change, seen 8 hr after dosing, was cytoplasmic vacuolation of tubular epithelial cells. Rabbits given a single oral dose of 120 mg citrinin/kg had regeneration of renal tubular epithelium accompanied by slight tubular cell necrosis when examined 7 days after dosing. Rabbits given multiple sublethal doses of citrinin (33.5 or 77 mg/kg daily for 7 days) had renal alterations of mild tubular degeneration and necrosis, and tubular regeneration.


Jan 1, 1979·The International Journal of Biochemistry·P E Taussig
Dec 1, 1977·Food and Cosmetics Toxicology·G A Sansing
Aug 1, 1978·Food and Cosmetics Toxicology·W H Jordan, W W Carlton
Oct 1, 1978·Food and Cosmetics Toxicology·W H JordanG A Sansing
Oct 1, 1978·Food and Cosmetics Toxicology·W H JordanG A Sansing
Feb 1, 1977·Food and Cosmetics Toxicology·W H JordonG A Sansing
May 1, 1977·Veterinary Pathology·D N KitchenJ Tuite
Aug 1, 1974·Food and Cosmetics Toxicology·W W CarltonJ Tuite
Jun 1, 1981·Urology·J S Vordermark
Dec 1, 1981·Food and Cosmetics Toxicology·N A MehdiJ Tuite
Jun 1, 1980·Experimental and Molecular Pathology·V G LockardR M O'Neal
Jan 1, 1980·Toxicology·R D PhillipsW L Williams
Sep 26, 1947·Science·Y WangC S Fan


May 1, 1992·Archives of Environmental Contamination and Toxicology·R C BraunbergL Friedman
Mar 1, 1989·Toxicology and Applied Pharmacology·D E MalarkeyP M Newberne
Dec 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C HanikaJ Tuite
Jan 12, 2010·Arhiv za higijenu rada i toksikologiju·Dubravka Flajs, Maja Peraica
Dec 30, 2006·Molecular Nutrition & Food Research·Annie Pfohl-Leszkowicz, Richard A Manderville
Jul 16, 2010·Journal of Food Science·Chun-Hsien LeeTzu-Ming Pan
Jan 1, 1984·Drug and Chemical Toxicology·J C PiccianoD E Rodwell
Jan 1, 1988·Critical Reviews in Toxicology·G LaurentP Maldague
Sep 13, 2017·Journal of the Science of Food and Agriculture·Nurshad Ali
Aug 30, 2008·Journal of Food Protection·Mitsuru Watanabe
May 1, 1986·Veterinary Pathology·C HanikaJ Tuite
Oct 29, 2020·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Ivana SpevakovaMarcela Capcarova

Related Concepts

Dose-Response Relationship, Drug
Kidney Tubular Necrosis, Acute
Lethal Dose 50
Chinchilla Rabbits

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Related Papers

The Veterinary Record
E B AbdelsalamA M Abdulmagid
Food and Cosmetics Toxicology
W H Jordan, W W Carlton
Avian Pathology : Journal of the W.V.P.A
N A MehdiJ Tuite
Food and Cosmetics Toxicology
N A MehdiJ Tuite
© 2021 Meta ULC. All rights reserved