Citrinin produces acute adverse changes in renal function and ultrastructure in pentobarbital-anesthetized dogs without concomitant reductions in [potassium]plasma

Toxicology
M E KrejciD A Koechel

Abstract

Citrinin's nephrotoxicity was examined in pentobarbital-anesthetized dogs under conditions that minimized or avoided significant changes in a number of its actions that could indirectly and adversely affect renal function and ultrastructure, such as, (i) major acute reductions in blood pressure and renal blood flow and, (ii) emesis and diarrhea that could lead to dehydration and electrolyte imbalances, especially hypokalemia. Slow intravenous injection of 20 mumol citrinin/kg to pentobarbital-anesthetized dogs did not induce any alterations in renal tissue ultrastructure or in any of the 23 whole blood, plasma or renal function parameters that were monitored over a 6-h post-citrinin period. On the other hand, 80 mumol citrinin/kg produced significant increases in the hematocrit and in the renal excretion rates of protein and glucose; modest reductions were noted in CIN, RBF and excretion rate of inorganic phosphorus. In addition, 80 mumol citrinin/kg induced ultrastructural lesions in the cells of the S2 proximal tubular segment, the thick ascending limb, the distal convoluted tubule and the collecting ducts. The glomeruli, S1 and S3 cells of the proximal tubule and the thin descending and ascending limbs of Henle's loop were u...Continue Reading

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Citations

Nov 27, 2007·Applied Microbiology and Biotechnology·Yii-Lih LinNan-Wei Su
Feb 12, 2005·The British Journal of Nutrition·Hui-Ting YangHsin-Ju Chou
Sep 21, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ting-Shuan WuBiing-Hui Liu
Aug 6, 2010·Journal of Clinical Microbiology·Xavier IriartChristine Aznar
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Oct 29, 2020·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Ivana SpevakovaMarcela Capcarova

Related Concepts

Anesthesia, Intravenous
Metazoa
Bacteriocidal Agents
Citrinin
Canis familiaris
Dose-Response Relationship, Drug
Hematocrit Procedure
Intravenous Injections
Kidney
Kidney Function Tests

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