Citrullinated histone H3, a marker of extracellular trap formation, is increased in blood of stable asthma patients

Clinical and Translational Allergy
Pawel KucziaStanislawa Bazan-Socha

Abstract

Emerging data indicates that extracellular traps (ETs), structures formed by various immune cell types, may contribute to the pathology of noninfectious inflammatory diseases. Histone hypercitrullination is an important step in ETs formation and citrullinated histone H3 (H3cit) is considered a novel and specific biomarker of that process. In the present study we have evaluated circulating H3cit in stable asthmatics and investigated its relationship with asthma severity, pulmonary function and selected blood and bronchoalveolar lavage (BAL) biomarkers. In 60 white adult stable asthmatics and 50 well-matched controls we measured serum levels of H3cit. In asthmatics we also performed bronchoscopy with BAL. We analyzed blood and BAL biomarkers, including interleukin (IL)-4, IL-5, IL-6, IL-10, IL-12p70, IL-17A and interferon γ. For statistical analysis, Mann-Whitney U-test, χ2 test, one-way ANCOVA, ROC curve analysis and univariate linear regression were applied. Independent determinants of H3cit were established in a multiple linear regression model. Asthma was characterized by elevated circulating H3cit (17.49 [11.25-22.58] vs. 13.66 [8.66-18.87] ng/ml, p = 0.03). In asthmatics positive associations were demonstrated between serum...Continue Reading

References

Jun 1, 1996·The Journal of Allergy and Clinical Immunology·L BorishS Wenzel
Jul 8, 2000·The European Respiratory Journal·B VrugtR Aalbers
Oct 12, 2002·Paediatric Respiratory Reviews·John W Wilson, Colin F Robertson
Apr 26, 2008·The American Journal of Cardiology·Stephen J OnufrakL Viola Vaccarino
Oct 27, 2009·Nature Medicine·Jun XuCharles T Esmon
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tobias A FuchsDenisa D Wagner
Feb 15, 2011·The Journal of Allergy and Clinical Immunology·Ryszard DworskiShida Yousefi
Jun 30, 2011·Journal of Thrombosis and Haemostasis : JTH·C T AmmolloC T Esmon
Dec 22, 2012·The European Respiratory Journal·Christof J MajoorElisabeth H Bel
Aug 31, 2013·The European Respiratory Journal·Wei-Sheng ChungJun-Jun Yeh
Sep 6, 2014·Cell Death and Differentiation·S TuguesB Becher
Sep 28, 2014·Critical Care : the Official Journal of the Critical Care Forum·Michael Liembo EkaneyRalf Alexander Claus
Nov 25, 2014·Journal of Internal Medicine·S M Opal, T van der Poll
Dec 19, 2014·Nature Immunology·Bart N Lambrecht, Hamida Hammad
Apr 25, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Matthew C TattersallJames H Stein
Jun 30, 2015·Critical Care Medicine·Yasir AlhamdiCheng-Hock Toh
Jan 26, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Thomas K WrightKatherine J Baines
Mar 29, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S Bazan-SochaA Undas
Jun 5, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sakiko MasudaAkihiro Ishizu
Nov 25, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D L PhamH-S Park
Mar 8, 2017·Nature Medicine·Selina K Jorch, Paul Kubes
Mar 11, 2017·Expert Opinion on Therapeutic Targets·Sindhu KoushikSriram Rajagopal
May 2, 2017·Nature Medicine·Marie ToussaintSebastian L Johnston
May 26, 2017·Cell Death & Disease·Eleanor SilkDaqing Ma
Aug 23, 2017·Scientific Reports·Baihong PanYongqing Li
Sep 26, 2017·The Journal of Allergy and Clinical Immunology·Valdirene S MunizJosiane S Neves
Oct 11, 2017·Journal of Innate Immunity·Ryan S DosterDavid M Aronoff
Oct 11, 2017·Nature Reviews. Immunology·Venizelos Papayannopoulos
Dec 2, 2017·American Journal of Respiratory and Critical Care Medicine·Bruce H CulverUNKNOWN ATS Committee on Proficiency Standards for Pulmonary Function Laboratories
Jul 22, 2018·Biochemical and Biophysical Research Communications·Jamie E MeeganSarah Y Yuan
Aug 18, 2018·Experimental & Molecular Medicine·Youngwoo ChoiHae-Sim Park
Feb 26, 2019·Frontiers in Immunology·Mohib UddinFrauke Pedersen
Apr 4, 2019·The Journal of Biological Chemistry·Victor S TapiaDavid Brough
May 9, 2019·Allergology International : Official Journal of the Japanese Society of Allergology·Pawel KucziaAnetta Undas
Sep 19, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Pawel KozlikStanislawa Bazan-Socha
May 8, 2020·Journal of Investigational Allergology & Clinical Immunology·R Pacholczak-MadejS Bazan-Socha

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Citations

Dec 16, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Yu ZhangPingsheng Chen
Jul 3, 2021·International Journal of Molecular Sciences·Stanislawa Bazan-SochaJan G Bazan

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Methods Mentioned

BETA
lavage
bronchoalveolar lavage
sedation
ELISA
biopsy

Software Mentioned

Statistica

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