Citrullination of self-proteins and autoimmunity

Scandinavian Journal of Immunology
B Rubin, G Sønderstrup

Abstract

Citrullination (deimination is an enzymatic, posttranslational conversion of arginine residues to citrulline residues) of joint-associated self-proteins may be a possible mechanism in the induction of autoimmune CD4 T-cell responses in rheumatoid arthritis. We have studied the immune response to normal or deiminated human fibrinogen (hFBG) in mouse strains expressing major histocompatibility complex (MHC) class II antigens similar to either RA-susceptible or non-susceptible HLA-DR4 alleles. Upon immunization with deiminated hFBG, all mouse strains analysed produced high amounts of anti-FBG antibodies, while relatively low levels of anti-citrulline antibodies and little or no anti-FBG antibodies crossreactive with mouse FBG (mFBG) were obtained. Mice immunized with normal hFBG also produced high amounts of anti-hFBG antibodies. However, whereas mice with MHC class II molecules similar to RA-non-susceptible HLA-DR4 alleles produced low levels of anti-hFBG antibodies with crossreactivity to mFBG, mouse strains with RA-susceptible HLA-DR4-equivalent MHC class II molecules contained high levels of such crossreactive anti-mFBG antibodies. Similar results were obtained with HLA-DR4*0401, human CD4-double-transgenic mice. However, none...Continue Reading

References

Dec 1, 1990·Immunological Reviews·R HolmdahlJ A Mo
Aug 4, 1988·Nature·M M Davis, P J Bjorkman
May 20, 1988·Cell·B Furie, B C Furie
Apr 1, 1973·The Journal of Experimental Medicine·B Rubin, H Wigzell
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·L FuggerG S McDevitt
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·V MalmströmR Holmdahl
Dec 1, 1995·Current Opinion in Immunology·A CoutinhoS Avrameas
Jun 1, 1997·Arthritis and Rheumatism·G F VerheijdenA M Boots
Jun 1, 1997·Scandinavian Journal of Immunology·V MalmströmR Holmdahl
Feb 14, 1998·The Journal of Clinical Investigation·G A SchellekensW J van Venrooij
Jul 3, 1998·The Journal of Clinical Investigation·N BussoA So
Aug 18, 1999·Immunological Reviews·V Taneja, C S David
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·J H BrownC Cohen
Jan 13, 2000·Immunological Reviews·G SønderstrupH O McDevitt
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z YangR F Doolittle
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P Y PereraS N Vogel
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Masson-BessièreG Serre
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y H YangJ A Hamilton
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B T Wipke, P M Allen
Aug 8, 2001·The Journal of Experimental Medicine·H JiD Mathis
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S T SmileyW W Hancock
Mar 1, 2002·Immunity·Hong JiDiane Mathis
Apr 17, 2002·The Journal of Experimental Medicine·Mariana MaccioniDiane Mathis
Jun 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Johan BäcklundRikard Holmdahl
Jul 3, 2002·Nature Reviews. Immunology·Stephen M Anderton, David C Wraith
Oct 9, 2002·The Journal of Experimental Medicine·Toru AtsumiToshio Hirano
Feb 20, 2003·The Journal of Experimental Medicine·Iris CaramalhoJocelyne Demengeot
Feb 28, 2003·Nature Immunology·Simon J DavisP Anton van der Merwe
Mar 12, 2003·The Journal of Experimental Medicine·Lawrence L JohnsonStephen T Smiley
May 15, 2003·Arthritis and Rheumatism·Mary E MorganRené E M Toes
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan A HillEwa Cairns
Aug 9, 2003·Springer Seminars in Immunopathology·Grete Sønderstrup

❮ Previous
Next ❯

Citations

Apr 9, 2008·The Journal of Experimental Medicine·Jonathan A HillEwa Cairns
Jan 12, 2010·Current Opinion in Rheumatology·Joseph Holoshitz
Nov 10, 2005·Arthritis Research & Therapy·Andrew KinlochPatrick J Venables
May 26, 2012·International Immunopharmacology·Geoffrey M ThieleLynell W Klassen
Mar 1, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Brian R LawsonArgyrios N Theofilopoulos
Jan 12, 2013·Protein & Cell·Lei YinPhilippa Marrack
Jan 3, 2013·Arthritis and Rheumatism·Tineke CantaertDominique Baeten
Mar 3, 2010·Immunological Reviews·Hüseyin UysalRikard Holmdahl
May 30, 2006·The International Journal of Biochemistry & Cell Biology·Bence GyörgyEdit I Buzás
Jun 15, 2007·Critical Reviews in Clinical Laboratory Sciences·Amalia RaptopoulouDimitrios T Boumpas
Nov 1, 2006·Arthritis and Rheumatism·Tineke CantaertDominique Baeten
May 1, 2006·Expert Review of Clinical Immunology·Andrew J KinlochPatrick J Venables
May 7, 2016·BMC Musculoskeletal Disorders·Akari SuzukiKazuhiko Yamamoto
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenzhong GuoLawrence J Wysocki
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peggy P HoWilliam H Robinson
Apr 29, 2021·Antioxidants & Redox Signaling·Maria Isabel Trejo-ZambranoFelipe Andrade

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.