PMID: 9164703Mar 1, 1997Paper

Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins

Canadian Journal of Physiology and Pharmacology
F GoubelJ M Gillardin

Abstract

Citrulline malate is known to improve performance in weakened muscles. The present experiment was designed to test the hypothesis that citrulline malate can limit the effect of endotoxins on muscle fatigability. Endotoxemia was induced in rats by injection of lipopolysaccharides from Klebsiella pneumoniae. Resistance to fatigue was quantified by measuring tension production during repetitive electrical stimulation of the isolated epitrochlearis muscle. Oral treatment by citrulline malate was found to increase resistance to fatigue in infected rats, whereas twitch tension was not modified. This demonstrates the efficacy of citrulline malate for limiting an increase in muscle fatigue elicited with bacterial endotoxins.

References

Feb 1, 1992·Neuroreport·O Güntürkün, P Deviche
Jun 1, 1987·Experimental Neurology·A M WiniarskiV R Edgerton
Jan 1, 1995·Fundamental & Clinical Pharmacology·F GoubelJ M Gillardin

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Citations

Jul 30, 2002·British Journal of Sports Medicine·D BendahanP J Cozzone
Dec 18, 2014·Journal of Sports Sciences·Paul T CutrufelloGerald S Zavorsky
Jul 13, 2007·Muscle & Nerve·Benoît GiannesiniDavid Bendahan
Feb 9, 2008·Muscle & Nerve·Benoit GiannesiniDavid Bendahan
Apr 14, 2010·Journal of Strength and Conditioning Research·Joaquín Pérez-Guisado, Philip M Jakeman
Jan 1, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Yuji HottaKazunori Kimura
Jan 26, 2016·Journal of Strength and Conditioning Research·Brian CunniffeMarco Cardinale
Jan 16, 2013·Fundamental & Clinical Pharmacology·Shilpa N KaoreNavinchandra M Kaore

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