Citrus aurantium increases seizure latency to PTZ induced seizures in zebrafish thru NMDA and mGluR's I and II

Frontiers in Pharmacology
Coral Rosa-FaleroJosé G Ortíz

Abstract

Epilepsy is a serious neurological condition and pharmacotherapy is not effective for all patients and causes serious adverse effects and pharmacokinetic and pharmacodynamic interactions. Natural products and ethnobotanical resources can help develop new therapeutic options for conditions like epilepsy. In Puerto Rico, ethnobotanical resources highlight the anxiolytic properties of a tea like preparation made from the leaves of the Citrus aurantium tree or bitter orange. Studies performed with essential oils from the peel of the fruit have shown to increase seizure latency to pentylenetetrazole (PTZ) and maximal electroshock seizure in mice. We characterized the extract composition, and used a model of PTZ induces seizures in the zebrafish and a receptor-ligand binding assay to determine if this preparation has anticonvulsant properties and its mechanism of action. We determined that the aqueous extract made from the leaves of the C. aurantium tree contains hesperidin, neohesperidin, and neohesperidin dihydrochalcone. Using our zebrafish model, we determined that exposure to the C. aurantium 28 mg/mL extract in aquarium water increases seizure latency by 119% compared to controls. We ruled out a mechanism involving GABAA recept...Continue Reading

References

Jul 1, 1996·Clinical Pharmacology and Therapeutics·B AmeerR L Rouseff
Dec 1, 1995·Progress in Neurobiology·H F Bradford
Apr 29, 1998·Progress in Neurobiology·S OzawaK Tsuzuki
Oct 26, 1999·Neuropharmacology·D D SchoeppJ A Monn
Mar 29, 2000·The Journal of Nutrition·A G Chapman
Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·K SudhaA Rao
Dec 25, 2002·Biological & Pharmaceutical Bulletin·Maria Isabel Roth Carvalho-Freitas, Mirtes Costa
Sep 13, 2003·European Journal of Pharmacology·Randal X MoldrichBrian S Meldrum
Oct 29, 2005·Life Sciences·Aline de Moraes PultriniMirtes Costa
May 16, 2006·Journal of the Neurological Sciences·Jorge UreMónica Perassolo
Jul 13, 2006·Epilepsy Research·Wolfgang Löscher, Dieter Schmidt
Mar 22, 2008·Brain Research Bulletin·Jae-Yeon JeongKyu-Won Kim
Oct 24, 2009·Epilepsy Research·Simon Waldbaum, Manisha Patel
May 1, 2010·Bulletin of the World Health Organization·Ana-Claire MeyerGretchen Birbeck
Jun 4, 2010·Expert Review of Neurotherapeutics·Joyce A CramerRichard H Mattson
Jun 16, 2010·Brain Research·Keith WongAllan V Kalueff
Nov 3, 2010·Neuropharmacology·F NicolettiJ P Pin
May 10, 2011·Brain Research·Winfried NeuhausChristian R Noe
May 18, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Lisa M Del Valle-MojicaJosé G Ortiz
May 12, 2012·Journal of Agricultural and Food Chemistry·Audrey ChanetChristine Morand
Feb 28, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ehsan KarimiHawa Z E Jaafar
Apr 18, 2013·Zebrafish·Allan V KalueffUNKNOWN Zebrafish Neuroscience Research Consortium
Jun 24, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Su-Chen Ho, Chun-Ting Kuo
Jan 1, 2012·Metabolites·Daniel A DiasUte Roessner
Jul 30, 2014·Iranian Red Crescent Medical Journal·Masoumeh NamaziSharareh Jannesari

❮ Previous
Next ❯

Citations

Jan 8, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Baoyue ZhangMeng Jin
Jun 16, 2021·Journal of Ethnopharmacology·Matthias S GeckMarco Leonti
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lujain Bader EddinShreesh Ojha

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

GraphPad Prism

Related Concepts

Related Feeds

Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is a form of of brain inflammation due to antibodies against NMDA receptors. Discover the latest research on anti-NMDA receptor encephalitis here.