Citrus Auraptene Induces Expression of Brain-Derived Neurotrophic Factor in Neuro2a Cells

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Yoshiko FurukawaMitsunari Nakajima

Abstract

(1) Background: Our published data have indicated that 1) auraptene (AUR), a citrus ingredient, has neuroprotective effects on the mouse brain, owing to its ability to suppress inflammation, such as causing a reduction in hyperactivation of microglia and astrocytes; 2) AUR has the ability to trigger phosphorylation (activation) of extracellular signal-related kinase (ERK) and cAMP response element-binding protein (CREB) in neuronal cells; 3) AUR has the ability to induce glial cell line-derived neurotrophic factor (GDNF) synthesis/secretion in rat C6 glioma cells. The well-established fact that the ERK-CREB pathway plays an important role in the production of neurotrophic factors, including GDNF and brain-derived neurotrophic factor (BDNF), prompted us to investigate whether AUR would also have the ability to induce BDNF expression in neuronal cells. (2) Methods: Mouse neuroblastoma neuro2a cells were cultured and the effects of AUR on BDNF mRNA expression and protein content were evaluated by RT-PCR and ELISA, respectively. (3) Results: The levels of BDNF mRNA and secreted BDNF were significantly increased by AUR in a dose- and time-dependent manner in neuro2a cells. (4) Conclusion: The induction of BDNF in neuronal cells migh...Continue Reading

References

Nov 1, 1984·Journal of Neurochemistry·S KumarJ de Vellis
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Aug 5, 2008·Neuroscience Letters·Francesco EpifanoMassimo Curini
Oct 20, 2010·Current Drug Targets·Salvatore Genovese, Francesco Epifano
Mar 13, 2012·International Journal of Molecular Sciences·Yoshiko FurukawaTakashi Yoshida
Jul 4, 2012·International Journal of Molecular Sciences·Yoshiko FurukawaMitsunari Nakajima
Jul 9, 2013·Neuropharmacology·Debabrata Panja, Clive R Bramham
Sep 11, 2013·Bioscience, Biotechnology, and Biochemistry·Yoshiaki AmakuraTakashi Yoshida
Jun 24, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Satoshi OkuyamaYoshiko Furukawa
Oct 13, 2015·Progress in Neurobiology·Zhongwu Liu, Michael Chopp
Nov 17, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Satoshi OkuyamaYoshiko Furukawa
Feb 5, 2016·Neurochemistry International·Isadora MatiasFlávia Carvalho Alcantara Gomes
Mar 10, 2017·International Journal of Molecular Sciences·Shang-Der ChenDing-I Yang
Apr 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoshiko FurukawaSatoshi Hibino
Jan 8, 2020·International Journal of Molecular Sciences·Yoshiko FurukawaMitsunari Nakajima

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Citations

Jun 23, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Shih Jen Tan, Intan Safinar Ismail
Jan 5, 2021·Chemical & Pharmaceutical Bulletin·Yoshiko FurukawaTakashi Yoshida
Jan 5, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshiko Furukawa

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Methods Mentioned

BETA
ELISA
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biosensis

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