Citrus hystrix leaf extract attenuated diabetic-cataract in STZ-rats.

Journal of Food Biochemistry
Nor Shahira Solehah UmranNur Iliyani Mohd Ishak

Abstract

Diabetic cataract causes severe vision loss. This study evaluated the effects of hesperidin-standardized Citrus hystrix leaf flavonoids-rich extract (CLE) on diabetic-cataract development. Streptozotocin-induced diabetic rats were orally given 150 and 300 mg CLE/kg body-weight. These were compared with non-treated diabetic or healthy rats as controls, over 8 weeks. The CLE gradually attenuated fasting blood glucose (FBG), biomarkers for inflammation (Tumor necrosis factor alpha TNF-α; prostaglandin E2 PGE2); vascular permeability, (Vascular endothelial growth factor VEGF); and oxidative stress, (malondialdehyde MDA). The diabetic cataract was significantly mitigated by the 150 mg CLE/kg dose. Good correlations were found between cataract incidence with FBG (r2  = 0.90), serum PGE2 (r2  = 0.91), MDA (r2  = 0.99), VEGF (r2  = 0.71), but not with TNF-α levels (r2  = 0.49) suggesting the serum FBG, PGE2, MDA, and possibly the VEGF levels may help to predict the cataract risks. The CLE mitigated cataract probably by attenuating hyperglycaemia, inflammation, lens fluid influx, vascular leakage, lens osmotic-imbalance, and fibers over-hydration. PRACTICAL APPLICATIONS: The study shows the flavonoids-rich Citrus hystrix leaf consumptio...Continue Reading

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Citations

Oct 4, 2020·Pharmaceuticals·Nattaporn Pattarachotanant, Tewin Tencomnao

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