Oct 30, 2018

City-wide metagenomics uncover antibiotic resistance reservoirs in urban beach and sewage waters

BioRxiv : the Preprint Server for Biology
Pablo FresiaGregorio Iraola

Abstract

Background: Microbial communities present in environmental waters constitute a reservoir for antibiotic resistant pathogens that impact human health. For this reason a diverse variety of water environments are being analyzed using metagenomics to uncover public health threats. However, the composition of these communities along the coastal environment of a whole city where sewage and beach waters are mixed, is poorly understood. Results: We shotgun-sequenced 20 coastal areas from the city of Montevideo (capital of Uruguay) including beach and sewage water samples to characterize bacterial communities and their virulence and antibiotic resistance repertories. We found that sewage and beach environments presented significantly different bacterial communities. Sewage waters harbored a higher prevalence and a more diverse repertory of virulence and antibiotic resistant genes mainly from well-known enterobacteria, including carbapenemases and extended-spectrum betalactamases reported in hospital infections in Montevideo. Additionally, we were able to genotype the presence of both globally-disseminated pathogenic clones as well as emerging antibiotic resistant bacteria in sewage waters. Conclusions: Our study represents the first in ...Continue Reading

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Mentioned in this Paper

Study
Enterobacteriaceae
Carbapenemase
Genes
Pathogenic Organism
Environment
Public Health Surveillance
Clone
Extended-spectrum beta lactamase
Microbial

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