PMID: 9544930Apr 17, 1998Paper

CJ-12,373, a novel topoisomerase II inhibitor: fermentation, isolation, structure elucidation and biological activities

The Journal of Antibiotics
T InagakiN Kojima

Abstract

A novel isochroman carboxylic acid CJ-12,373 was isolated from Penicillium sp. CL22557. CJ-12,373 inhibits both DNA gyrase-mediated supercoiling and relaxation without the formation of a cleavage intermediate, suggesting that CJ-12,373 inhibits DNA gyrase at a stage distinct from the religation step. CJ-12,373 is not selective for procaryotic DNA gyrase as it also inhibits relaxation mediated by eukaryotic topoisomerase II. The antimicrobial potency of CJ-12,373, however, is largely attributed to its inhibition of DNA gyrase.

Citations

Oct 2, 2002·Bioscience, Biotechnology, and Biochemistry·Keitarou Suzuki, Masaru Uyeda
Aug 30, 2017·Natural Product Reports·Patrick D Brown, Andrew L Lawrence
Mar 3, 2020·Fitoterapia·Ting DingYun-Heng Shen
Dec 4, 2015·Journal of the American Chemical Society·Ken-Ichi TakaoKin-Ichi Tadano
Apr 16, 2013·Chemical Reviews·Jin-Ming GaoJian-Chun Qin
Jan 25, 2014·Journal of Natural Products·David R McMullinJ David Miller

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