CKbeta8, a novel CC chemokine that predominantly acts on monocytes

FEBS Letters
U ForssmannM Baggiolini

Abstract

We have studied the biological properties of a new human CC chemokine, CKbeta8, consisting of 99 amino acids including six cysteines. CKbeta8 mRNA transcripts were induced in monocytes by IL-1beta and, to a lesser extent, by IFNgamma, and were detected in RNA extracted from normal human liver and gastrointestinal tract. CKbeta8 is chemotactic for monocytes, but is inactive on IL-2 conditioned T lymphocytes, eosinophils and neutrophils. Desensitization experiments indicate that CKbeta8 and MIP-1beta completely share receptors on monocytes and that the CKbeta8 receptor, which appears to differ from the known ones, is also recognized by MCP-1, MCP-2, MCP-3, MCP-4, MIP-1alpha and RANTES.

References

Nov 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y TanimotoI Kimura
Sep 1, 1992·The Journal of Experimental Medicine·R AlamJ A Grant
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D Miller, M S Krangel
May 1, 1991·Cytokine·T J Schall
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
May 1, 1988·The Journal of Experimental Medicine·P PeveriM Baggiolini
Dec 1, 1994·Current Opinion in Immunology·T J Schall, K B Bacon
Oct 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P LoetscherB Moser
Mar 1, 1994·Immunology Today·M Baggiolini, C A Dahinden
Jan 1, 1993·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·K KasaharaS L Kunkel
May 1, 1996·The Journal of Experimental Medicine·M UguccioniM Baggiolini

❮ Previous
Next ❯

Citations

Jun 10, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Chu-Sook KimRina Yu
Apr 18, 1998·Biochimica Et Biophysica Acta·K ShoudaiH Nomiyama
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·A PardigolH J Mägert
May 11, 1999·DNA and Cell Biology·S FukudaH Nomiyama
Apr 23, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·H NomiyamaO Yoshie
Mar 2, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Leticia CastilloJames A de Lemos
Jan 21, 2011·PloS One·Mairi H McLeanEmad M El-Omar
May 16, 2009·Journal of the American Society of Nephrology : JASN·Maarten NaesensMinnie M Sarwal
Dec 10, 2003·British Journal of Pharmacology·Aram ElagozPaola M C Lembo
Mar 7, 2009·Biochemical and Biophysical Research Communications·Kyu Yeon HanJiyoung Kim
Mar 21, 2007·Nature Genetics·Takanori KitamuraMakoto M Taketo
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yasuo ObaG David Roodman
Feb 6, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jan DäbritzDirk Foell
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K TamadaL Chen
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Carla BoscoLuigi Varesio
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhenhua MiaoRobert Berahovich
May 30, 2017·Frontiers in Cellular and Infection Microbiology·Fabio Arruda-SilvaMarco A Cassatella
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hermann NovakMaximilian Woisetschläger
Nov 13, 2020·Nucleic Acids Research·Clarissa S SantosoJuan I Fuxman Bass
Nov 14, 2020·International Journal of Molecular Sciences·Jan KorbeckiIrena Baranowska-Bosiacka
Apr 19, 2011·The Journal of Allergy and Clinical Immunology·Julie A PoposkiAtsushi Kato
Mar 21, 2007·Biochimica Et Biophysica Acta·Yong-Hyun ShinJiyoung Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.