CKD Increases Carbonylation of HDL and Is Associated with Impaired Antiaggregant Properties.

Journal of the American Society of Nephrology : JASN
Nans FlorensChristophe O Soulage

Abstract

CKD is associated with increased oxidative stress that correlates with occurrence of cardiovascular events. Modifications induced by increased oxidative stress particularly affect circulating lipoproteins such as HDL that exhibit antiatheromatous and antithrombotic properties in vitro. To explore the specific role of oxidative modifications of HDL in CKD and their effect on the platelet-targeting antiaggregant properties of HDL, we used a CKD (5/6 nephrectomy) rabbit model. For ex vivo assessment of the antiaggregant properties of HDL, we collected blood samples from 15 healthy volunteers, 25 patients on hemodialysis, and 20 on peritoneal dialysis. We analyzed malondialdehyde, 4-hydroxynonenal (HNE), and 4-hydroxy-2-hexenal protein adduct levels. Platelet aggregation and activation were assessed by aggregometry, thromboxane B2 assay, or FACS. We modified HDL from controls by incubating it overnight at 37°C with 100 µM of HNE. HDL from CKD rabbits and patients on hemodialysis had HNE adducts. The percentage of platelet aggregation or activation induced by collagen was significantly higher when platelets were incubated with HDL from CKD rabbit and hemodialysis groups than with HDL from the control group. In both rabbits and human...Continue Reading

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Citations

Jan 5, 2021·European Heart Journal·Thimoteus SpeerDanilo Fliser
May 5, 2021·Journal of the American Society of Nephrology : JASN·Constance C F M J BaatenHeidi Noels
May 12, 2021·Nature Reviews. Nephrology·Heidi NoelsJoachim Jankowski
Aug 19, 2021·Molecular Aspects of Medicine·Zhuojun WuJoachim Jankowski
Dec 16, 2021·Journal of the American Society of Nephrology : JASN·Stefanie SteigerHans-Joachim Anders

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