PMID: 11319029Apr 25, 2001Paper

CKS1At overexpression in Arabidopsis thaliana inhibits growth by reducing meristem size and inhibiting cell-cycle progression

The Plant Journal : for Cell and Molecular Biology
Lieven De VeylderD Inzé

Abstract

The SUC1/CKS1 proteins associate with cyclin-dependent kinases (CDKs) and play an essential role in the regulation of the cell cycle. Recently, an Arabidopsis thaliana SUC1/CKS1 homologous gene, designated CKS1At, has been cloned. Here, overexpression of CKS1At in Arabidopsis is shown to reduce leaf size and root growth rates. Reduced root growth resulted primarily from an increase of the cell-cycle duration and a shortening of the meristem. Endoreduplication was unaffected. The increased cell-cycle duration was associated with an equal extension of both the G1 and G2 phases. This inhibition was due to the binding of CDK subunits with CDKs. The reduced growth rates in response to altered cell-cycle gene expression demonstrates a direct dependence of plant growth rates on cell-cycle regulation.

References

Oct 4, 1991·Cell·W G Dunphy, A Kumagai
Dec 1, 1994·Seminars in Cell Biology·J Pines
Dec 1, 1993·Seminars in Cell Biology·S Atherton-FesslerH Piwnica-Worms
Dec 22, 1999·The Journal of Biological Chemistry·D PatraW G Dunphy
May 16, 2000·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·T Beeckman, R Viane
Jun 13, 2000·Nature·C E CockcroftJ A Murray
Nov 23, 2000·Plant Molecular Biology·J JoubèsJ P Renaudin
Jun 1, 1994·Trends in Cell Biology·W G Dunphy
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D ValvekensM Van Lijsebettens
Jul 1, 1991·Plant Physiology·D W GalbraithS Knapp

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Citations

Jun 18, 2004·The Plant Journal : for Cell and Molecular Biology·Steven VandenabeeleFrank Van Breusegem
Jan 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Laurens PauwelsAlain Goossens
Aug 18, 2009·The Plant Journal : for Cell and Molecular Biology·Lixia HuangChengwei Yang
Jun 2, 2005·Nature Cell Biology·Crisanto Gutierrez
May 26, 2006·Plant Molecular Biology·Fabio Fiorani, Gerrit T S Beemster
Jul 25, 2009·Plant Molecular Biology·Cristian Antonio RojasPaulo Cavalcanti Gomes Ferreira
Jan 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jennifer C Fletcher
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kristiina HimanenTom Beeckman
May 26, 2006·Plant Molecular Biology·Vasilis C Gegas, John H Doonan
Dec 30, 2014·Journal of Experimental Botany·François BizetMarie-Béatrice Bogeat-Triboulot
Apr 1, 2004·The Plant Journal : for Cell and Molecular Biology·Stephanie Breuil-BroyerChristophe Trehin
Mar 29, 2007·The New Phytologist·Dennis Francis
Oct 20, 2001·Current Opinion in Plant Biology·T Potuschak, P Doerner
Feb 20, 2003·Developmental Biology·Alessia Para, Annika Sundås-Larsson
Jan 10, 2002·Developmental Cell·James A H Murray
Dec 8, 2004·Plant Physiology·Rosa Maria BarrôcoGilbert Engler
Jun 8, 2004·Plant Physiology·Gerrit WestGerrit T S Beemster
Apr 16, 2005·Current Opinion in Biotechnology·Gerrit T S BeemsterDirk Inzé

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