PMID: 6972113Jan 1, 1980Paper

Cl- dependence of HCO3- transport in frog gastric mucosa

Upsala Journal of Medical Sciences
Gunnar Flemström

Abstract

Frog (Rana temporaria) fundic mucosae in vitro were pretreated with the histamine H2 receptor antagonist Metiamide (10(-3)M, nutrient side) until net H+ secretion had ceased and a steady rate of HCO3- transport (luminal alkalinization) was titrated. Removal of Cl- with SO4(2) or isethionate replacement from solutions bathing both sides of the mucosa abolished luminal alkalinization. Readdition of Cl- to the luminal side only reestablished full rates of HCO3- transport. Nutrient (serosal) side Cl- had no effect in this aspect. The results support the previous suggestion that the gastric HCO3- transport process is located at the luminal membrane of the surface epithelial cells and indicate that it occurs by (electroneutral) HCO3-/Cl- exchange.

References

Jun 1, 1979·European Journal of Clinical Investigation·C Johansson, B Kollberg
Apr 1, 1975·The American Journal of Physiology·G Flemström, T G Sachs
Jul 1, 1977·The American Journal of Physiology·Y Matsumoto, A M McPhedran
Jan 1, 1969·The American Journal of Physiology·J G Forte
Jun 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·N Sugai, S Ito
Jan 1, 1980·Brain Research Bulletin·G L Kauffman
Sep 20, 1957·The Journal of General Physiology·E HEINZ, R P DURBIN

❮ Previous
Next ❯

Citations

May 6, 2004·Upsala Journal of Medical Sciences·Mia Phillipson
Jan 8, 2017·BMC Microbiology·Lucia Gonzales-SilesÅsa Sjöling
Apr 1, 2005·American Journal of Physiology. Cell Physiology·Jie XuManoocher Soleimani
Dec 14, 2004·American Journal of Physiology. Cell Physiology·Adrian Allen, Gunnar Flemström
Jan 24, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mia PhillipsonLena Holm
Aug 2, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jie XuManoocher Soleimani
Jan 1, 1982·The Journal of Membrane Biology·J F White, M A Imon
Nov 14, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·L DebellisS Curci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.