Abstract
There are few reports on the migration of CLA+ T cells through E-selectin in cutaneous lichen planus, with only one study on oral lichen planus (OLP). This study aimed to analyze CLA expression and assess whether there is a correlation with E-selectin (CD62E) in OLP lesions. Biopsies were performed on 11 patients including two areas: one without clinical and histopathological features of OLP [perilesional group (PLG)] and the other with clinical and histopathological features of OLP [OLP group (OLPG)]. The specimens obtained were divided into two: One was fixed in formalin for routine analysis (H&E), and the other was frozen for CD3, CD4, CD8, CLA, and CD62E immunofluorescence markers. More CD4+ (median 1409, range 860-2519), CD8+ (median 1568, range 654-3258), and CLA+ T cells (median 958, range 453-2198) and higher CD62E expression (median 37, range 27-85) were identified in OLPG (P = 0.003; P = 0.003; P = 0.004; P = 0.003, respectively) than those in PLG. The median prevalence analysis was also significantly higher for CLA+CD8+ T cells in OLPG (OLPG = 39.4%, range 18.4-64.2; PLG = 29.4%, range 12.1-47.1) (P = 0.026). None of the correlations between CD3+ or CLA+ T cells and CD62E in OLPG and in PLG were significant. The sign...Continue Reading
References
Feb 28, 1991·Nature·L J PickerE C Butcher
Feb 28, 1991·Nature·Y ShimizuW Newman
Dec 1, 1981·The British Journal of Dermatology·A K BhanM C Mihm
Jan 28, 1994·Cell·T A Springer
Jan 1, 1994·Journal of Periodontal Research·E GemmellG J Seymour
Nov 1, 1995·Journal of Periodontal Research·E R PietrzakL J Walsh
Jun 1, 1996·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J A RegeziT H McCalmont
Jul 1, 1997·British Journal of Rheumatology·S M JonesN J McHugh
Nov 14, 1997·Nature·R C FuhlbriggeT S Kupper
Dec 31, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L J WaltonP M Farthing
Dec 10, 1999·The New England Journal of Medicine·C Robert, T S Kupper
Sep 6, 2000·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A SklavounouA Karameris
Jan 3, 2001·Clinics in Dermatology·P B SugermanM Bigby
Jun 23, 2001·Archives of Oral Biology·B AuJ B Hay
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K RezavandiR F Wilson
Sep 26, 2002·Journal of Clinical Periodontology·N U ZitzmannJ Lindhe
Feb 18, 2003·Australian Dental Journal·P B Sugerman, N W Savage
Sep 13, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·E H van der Meij, I van der Waal
Feb 4, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Kobkan ThongprasomMantharop Chaimusig
May 26, 2007·Cell Biology International·Mahmoud R Hussein
Jul 5, 2007·Clinical and Experimental Dermatology·C Bascones-IlundainA Bascones-Martinez
Jul 20, 2007·Journal of Oral Science·Sumairi B IsmailRosnah B Zain
May 26, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Maryam RadNima Izadi
Feb 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Eric A MurphyDavid A Cheresh
Aug 17, 2010·Medicina oral, patología oral y cirugía bucal·F Fernández-GonzálezJ-M Gándara-Rey
Oct 7, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M R RoopashreeAbhilasha Shukla
Oct 4, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Giuseppe Alessandro ScardinaPietro Messina
Mar 23, 2012·Journal of Oral and Maxillofacial Pathology : JOMFP·Nitasha MittalSangeeta Palaskar
Aug 16, 2012·Clinical Oral Investigations·Marilena VeredDan Dayan
Jan 18, 2013·Advanced Biomedical Research·Parichehr GhalayaniZahra Saberi
May 11, 2013·Archives of Oral Biology·Márcia Rodrigues PayerasFernanda Gonçalves Salum