PMID: 7521325Sep 1, 1994Paper

Clara cell 10 kDa protein mRNA in normal and atypical regions of human respiratory epithelium

International Journal of Cancer. Journal International Du Cancer
S M JensenR Ilona Linnoila

Abstract

We used RNA-RNA in situ hybridization to study expression of the human CC10 gene in morphologically normal and atypical areas of 32 non-neoplastic lung specimens resected from 26 non-small cell lung cancer patients. We scored strong, moderate or weak levels of CC10 mRNA expression in 3 distinct lung compartments. In morphologically normal lungs, strong and moderate levels of CC10 mRNA were observed in bronchioli and bronchi, respectively, but the expression was rarely observed in the alveolar region. Distinct alterations in CC10 mRNA expression were noted in specific histologic abnormalities within bronchi and the alveolar region. CC10 hybridization signal decreased markedly in bronchi containing diffuse goblet cell hyperplasia or squamous metaplasia, while CC10 mRNA expression remained unchanged in bronchi with basal cell hyperplasia or focal goblet cell hyperplasia. Bronchiolar CC10 mRNA levels remained unchanged in sections containing abnormalities elsewhere. Interestingly, in alveoli with bronchiolization of the alveoli, high levels of CC10 mRNA were observed. These regions also contained strongly stained keratin 14-positive cells, which may indicate a concurrent metaplastic process. In lungs with morphologic atypias, no co...Continue Reading

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Citations

Feb 1, 1996·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J ZhouR I Linnoila
Aug 17, 1999·Pathology, Research and Practice·P J Barth, B Müller
Jun 18, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sandra Jensen-TaubmanR Ilona Linnoila
Apr 13, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Philip L BallardMichael A Matthay
Nov 13, 2012·American Journal of Respiratory and Critical Care Medicine·Deog Kyeom KimUNKNOWN ECLIPSE, ICGN, and COPDGene Investigators
Jun 16, 2004·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Cedric HermansIan R Doyle
Aug 10, 2000·The American Journal of Pathology·T BetsuyakuR M Senior
Jan 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I A LaingUNKNOWN Perth Infant Asthma Follow-up Cohort
Jul 1, 1997·Cancer Treatment Reviews·P VermylenJ P Sculier
Mar 23, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·R Ilona LinnoilaH Leighton Grimes
Mar 25, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert J HomerJack A Elias
Apr 11, 2001·Inhalation Toxicology·C AlbrechtP J Borm
Feb 24, 2001·Annals of the New York Academy of Sciences·M NordG Suske
Oct 25, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·C M CastroR I Linnoila
Oct 27, 2004·Bioscience, Biotechnology, and Biochemistry·Hajime Yoshisue, Kazuhide Hasegawa
Apr 8, 1998·The American Journal of Physiology·G J PelletierB P Hackett
Feb 24, 2001·Annals of the New York Academy of Sciences·F BroeckaertA Bernard
Oct 21, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Han ChangPinpin Lin
Feb 24, 2001·Annals of the New York Academy of Sciences·R I LinnoilaA Malkinson
Jun 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Suil KimJay A Nadel
Feb 18, 1998·International Journal of Cancer. Journal International Du Cancer·S M Jensen-TaubmanR I Linnoila

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