Clara cell protein 16 and eosinophil cationic protein production in chronically inflamed sinonasal mucosa

International Forum of Allergy & Rhinology
Cveta Spadijer-MirkovićDanilo Vojvodić

Abstract

Clara cell protein 16 (CC16) is an anti-inflammatory protein mainly expressed in the epithelial cells in the upper and lower airways. Eosinophil cationic protein (ECP) is an important marker of eosinophil activity in chronic inflammatory sinonasal diseases. The aim of this study was to evaluate mucosal production of CC16 and ECP in patients with perennial allergic rhinitis (PAR), nonallergic and allergic patients with chronic rhinosinusitis with nasal polyposis (CRSwNP), before and after nasal corticosteroid administration. Twenty patients with PAR, 20 nonallergic CRSwNP patients, 20 allergic CRSwNP patients, and 20 healthy controls were included. Mucosal cytology samples were taken from all participants for quantification of eosinophils. CC16 and ECP levels were measured in the nasal secretion samples. The patients with chronic sinonasal inflammation were treated with fluticasone nasal spray for 14 days. Nasal symptoms assessment, cytological examination, and CC16 and ECP nasal fluid measurements were performed before and after the corticosteroid treatment. Mean CC16 concentrations in nasal secretions were significantly lower in patients with PAR (p < 0.05) and allergic CRSwNP patients (p < 0.01) compared to controls. Mean ECP...Continue Reading

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Citations

May 6, 2016·International Forum of Allergy & Rhinology·Sarah K Wise
Oct 5, 2018·Arhiv za higijenu rada i toksikologiju·Aleksandar PerićDanilo Vojvodić
Nov 21, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Sophie GohyCharles Pilette
Jan 9, 2020·The Annals of Otology, Rhinology, and Laryngology·Su Il KimYoung-Gyu Eun
Feb 27, 2021·American Journal of Rhinology & Allergy·Oh Eun KwonSeong-Gyu Ko

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