Clarifying associations between cortical thickness, subcortical structures, and a comprehensive assessment of clinical insight in enduring schizophrenia

Schizophrenia Research
Sophie BélandMartin Lepage

Abstract

The relationship between poor insight and less favorable outcomes in schizophrenia has promoted research efforts to understand its neurobiological basis. Thus far, research on neural correlates of insight has been constrained by small samples, incomplete insight assessments, and a focus on frontal lobes. The purpose of this study was to examine associations of cortical thickness and subcortical volumes, with a comprehensive assessment of clinical insight, in a large sample of enduring schizophrenia patients. Two dimensions of clinical insight previously identified by a factor analysis of 4 insight assessments were used: Awareness of Illness and Need for Treatment (AINT) and Awareness of Symptoms and Consequences (ASC). T1-weighted structural images were acquired on a 3 T MRI scanner for 110 schizophrenia patients and 69 healthy controls. MR images were processed using CIVET (version 2.0) and MAGeT and quality controlled pre and post-processing. Whole-brain and region-of-interest, vertex-wise linear models were applied between cortical thickness, and levels of AINT and ASC. Partial correlations were conducted between volumes of the amygdala, thalamus, striatum, and hippocampus and insight levels. No significant associations betw...Continue Reading

Citations

Aug 4, 2020·Schizophrenia Bulletin·Matthias KirschnerBratislav Mišić
Nov 7, 2019·The British Journal of Psychiatry : the Journal of Mental Science·Anthony S David
Dec 5, 2019·NeuroImage. Clinical·Carlos Muñoz-NeiraCatherine Pennington
Aug 18, 2021·Psychiatry Research. Neuroimaging·Teemu MäntyläTuukka T Raij

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