Clarifying of the potential mechanism of Sinisan formula for treatment of chronic hepatitis by systems pharmacology method

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Zhiming ShuChaobin Liu

Abstract

Chronic hepatitis is a general designation class of diseases, which results in different degrees of liver necrosis and inflammatory reaction, followed by liver fibrosis, may eventually develop into cirrhosis. However, the molecular pathogenesis of chronic hepatitis is too complex to elucidate. Herbal medicines, featured with multiple targets and compounds, have long displayed therapeutic effect in treating chronic hepatitis, though their molecular mechanisms of contribution remain indistinct. This research utilized the network pharmacology to confirm the molecular pathogenesis of chronic hepatitis through providing a comprehensive analysis of active chemicals, drug targets and pathways' interaction of Sinisan formula for treating chronic hepatitis. The outcomes showed that 80 active ingredients of Sinisan formula interacting with 91 therapeutic proteins were authenticated. Sinisan formula potentially participates in immune modulation, anti-inflammatory and antiviral activities, even has regulating effects on lipid metabolism. These mechanisms directly or indirectly are involved in curing chronic hepatitis by an interaction way. The network pharmacology based analysis demonstrated that Sinisan has multi-scale curative activity i...Continue Reading

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Citations

Sep 26, 2019·Anais Da Academia Brasileira De Ciências·Zhiming ShuChaobin Liu
Jul 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Fangzhou LiuYang Yang
Apr 4, 2019·Chinese Journal of Integrative Medicine·Ting-Ting LuoJiao Guo
May 15, 2020·Combinatorial Chemistry & High Throughput Screening·Ling ShiZe-Feng Wang

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