Clarifying the dilemmas about inhalation techniques for dry powder inhalers: integrating science with clinical practice.

Primary Care Respiratory Journal : Journal of the General Practice Airways Group
Wahida Azouz, H Chrystyn

Abstract

This review integrates pharmaceutical science with routine clinical practice to explain why inhalation manoeuvres through a dry powder inhaler (DPI) should start with a gentle exhalation, away from the inhaler. Place the inhaler in the mouth and ensure the lips form a tight seal. This should be followed by an immediate forceful inhalation that is as fast as possible and continued for as long as the patient can comfortably achieve. Although this is universally accepted, there has been a lot of attention on inhalation flow as an indicator of adequate inspiratory effort. This has led to the wrong assumption that inhalation flows through each DPI should be the same, and that low flows through some DPIs suggest that dose delivery is impaired. Most miss the concept that inhalation flow together with the resistance of the DPI combine to create a turbulent energy which de-aggregates the formulation and provides an effective emitted dose. A low flow through a DPI with high resistance generates the same turbulent energy as fast flow with low resistance. Therefore, depending on the device, different inhalation flows are compatible with potentially effective use. Flow measurements should be a guide to train patients to inhale fast...Continue Reading

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Jul 1, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·L Pekka MalmbergSatu Lähelmä
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Apr 21, 2021·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Agata DoroszArkadiusz Moskal

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