Clarithromycin and azithromycin induce apoptosis of activated lymphocytes via down-regulation of Bcl-xL

International Immunopharmacology
Syunji MizunoeMasaru Nasu

Abstract

To evaluate the anti-inflammatory action of macrolide antibiotics, we examined whether macrolide antibiotics could induce apoptosis of activated lymphocytes. The proportion of apoptotic cells was augmented by clarithromycin (CLR) and azithromycin (AZM) compared with control. There was no significant difference in Fas and Fas-ligand expression between the control and macrolide-treated groups. CLR and AZM inhibited the expression of Bcl-xL compared with that of control. Our results suggest that CLR and AZM enhance apoptosis of activated lymphocytes by down-regulation of Bcl-xL.

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Citations

Jan 16, 2010·The Journal of Antibiotics·Rodopi StamatiouApostolia Hatziefthimiou
Apr 27, 2010·BMC Microbiology·Saira AhmadMonique L van Hoek
Jul 11, 2012·Mediators of Inflammation·Helen C SteelCharles Feldman
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Mar 1, 2011·Clinical Transplantation·Gundeep S DhillonDavid Weill
Mar 11, 2015·Journal of Cellular Biochemistry·Brittany MeadDaniel Jones
Mar 14, 2012·International Immunopharmacology·Syh-Jae LinPei-Yzu Lee
Apr 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara KiesewetterMarkus Raderer
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May 21, 2011·International Archives of Allergy and Immunology·Syh-Jae LinMing-Ling Kuo
Nov 9, 2011·The Korean Journal of Hematology·Masashi Ohe, Satoshi Hashino
Feb 9, 2013·Annals of Plastic Surgery·Ping YangXuan-Fen Zhang
Sep 1, 2017·Translational and Clinical Pharmacology·Masashi OheMitsuru Sugiura
Oct 30, 2020·Frontiers in Immunology·Abdul Wahid AnsariQutayba Hamid

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