Abstract
We investigated the inhibitory effect of clarithromycin, a 14-membered ring macrolide antibiotic, on tumor-induced angiogenesis in vivo using a mouse dorsal air sac model. The inhibitory effect of clarithromycin was dose-dependent, and 100 mg/kg of clarithromycin administered intraperitoneally twice a day reduced the area of dense capillary network to about 30% that of the control. However, in concentrations up to 50 microM clarithromycin had no effect on lung cancer cells and human vascular endothelial cell growth, endothelial cell migration, or lung cancer cell production of the angiogenesis-inducing factors interleukin-8 and vascular endothelial growth factor. Clarithromycin in concentrations greater than 10 microM inhibited endothelial cell tube formation on Matrigel in a dose-dependent manner. These data suggest clarithromycin is a potent inhibitor of tumor-induced angiogenesis that exerts its effect by inhibiting endothelial cell tube formation, and may be a possible candidate for therapeutic application.
References
Oct 29, 1992·Nature·K H PlateW Risau
Jan 1, 1992·Life Sciences·S H Song, A E Takemori
Sep 1, 1992·Journal of Cellular Physiology·P S WrightA J Bitonti
Jan 1, 1992·Life Sciences·S KonnoT Takahashi
Oct 1, 1992·Journal of Cellular Physiology·M S PepperJ D Vassalli
Sep 8, 1989·Cell·D S GrantH K Kleinman
Dec 28, 1995·The New England Journal of Medicine·J Folkman
May 1, 1994·The Journal of Experimental Medicine·D R SmithR M Strieter
Jul 1, 1995·The Journal of Experimental Medicine·A L AngiolilloG Tosato
Jul 1, 1993·The Journal of Clinical Investigation·T AbeM Kuwano
Aug 1, 1993·Drugs·L B BarradellD McTavish
May 25, 1995·Biochemical and Biophysical Research Communications·H TakizawaK Ito
Jan 1, 1995·Chemotherapy·K HamadaN Narita
Dec 1, 1994·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·K MaedaK Hamada
Oct 1, 1994·Infection and Immunity·K OishiK Matsumoto
Oct 1, 1993·Chest·S Umeki
Jan 1, 1993·The American Review of Respiratory Disease·J KadotaK Hara
Citations
Jun 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Mustafa PehlivanSacide Pehlivan
Feb 15, 2005·Urology·Mustafa PehlivanZiya Kirkali
Sep 22, 2001·Cancer Letters·K MatsuiH Nanba
Feb 5, 2000·Cancer Letters·J YatsunamiS Hayashi
Apr 30, 2003·Seminars in Oncology·M A DimopoulosN Anagnostopoulos
Jun 1, 2000·The Journal of Cell Biology·J Y PanD S Silberstein
Jul 1, 2015·Current Eye Research·Hironori UeharaBalamurali K Ambati
Sep 2, 2008·British Journal of Haematology·T C M MorrisJ Quinn
Feb 18, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Shunsaku TakeiMasayoshi Yokoyama
Dec 16, 2016·PloS One·Kazuhiro HirasawaKeisuke Miyazawa
Jan 25, 2002·Journal of Cellular Physiology·Mayumi AbeYasufumi Sato
Sep 5, 2018·The Journal of International Medical Research·Xin MaLisheng Yu
Sep 12, 2000·Circulation·M SimonsT K Rosengart
Nov 4, 2000·Clinical and Diagnostic Laboratory Immunology·L W ChowW I Wei
Nov 11, 2019·Journal of Ovarian Research·Bo ZhouHongbin Cai
May 14, 2020·Antibiotics·Joy BraunUlrike Ritz
Mar 4, 2020·Cell Death & Disease·Giulia PetroniAnnarosa Arcangeli
Nov 22, 2020·Biomedicines·Ahmad QasemSaleh A Naser
Jul 3, 2021·Cancers·Christina PfabNahed El-Najjar