Clarithromycin is an effective immunomodulator when administered late in experimental pyelonephritis by multidrug-resistant Pseudomonas aeruginosa

BMC Infectious Diseases
Evangelos J Giamarellos-BourboulisHelen Giamarellou

Abstract

To apply clarithromycin as an immunomodulatory treatment in experimental urosepsis by multidrug-resistant Pseudomonas aeruginosa. Acute pyelonephritis was induced in 40 rabbits after inoculation of the test isolate in the renal pelvis. Therapy was administered upon signs of sepsis in four groups: A, controls; B, intravenous clarithromycin; C, amikacin; and D, both agents. Survival and vital signs were recorded; blood was sampled for culture and estimation of pro-inflammatory mediators; monocytes were isolated for determination of apoptotic rate and ex vivo TNFalpha secretion. Quantitative cultures and biopsies of organs were performed after death. Increased rectal temperature and oxygen saturation were found in groups B and D compared to A and C. Mean survival of groups A, B, C and D was 2.65, 7.15, 4.25 and 8.70 days respectively. No differences were noted between groups concerning bacterial load in blood and tissues and serum endotoxins. Serum MDA and total caspase-3 activity of monocytes of group D decreased following treatment compared to other groups. Negative correlation was detected between cytoplasmic caspase-3 and ex vivo secretion of TNFalpha of blood monocytes of group A; similar correlation was not found for any oth...Continue Reading

References

Jan 11, 2000·The Journal of Antimicrobial Chemotherapy·K Q BuiD P Nicolau
Apr 20, 2001·Intensive Care Medicine·P Arndt, E Abraham
Nov 8, 2001·European Journal of Pharmacology·O CulićM J Parnham
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Louis VincentMarc-Jacques Dubois
Jul 9, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Rajiv Agarwal, Shawn D Chase
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Dec 25, 2003·Antimicrobial Agents and Chemotherapy·Evangelos J Giamarellos-BourboulisHelen Giamarellou

❮ Previous
Next ❯

Citations

May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Evangelos J Giamarellos-BourboulisHelen Giamarellou
Dec 23, 2010·Immunotherapy·Anastasia Antonopoulou, Evangelos J Giamarellos-Bourboulis
Oct 3, 2006·Expert Review of Anti-infective Therapy·Paolo Grossi, Daniela Dalla Gasperina
May 2, 2008·Expert Opinion on Investigational Drugs·Garyphallia Poulakou, Helen Giamarellou
May 18, 2016·Journal of Medicinal Chemistry·Gopal R BommineniPeter J Tonge
Jun 16, 2015·The Journal of Surgical Research·George DimopoulosThomas Tsaganos
Oct 16, 2007·International Journal of Antimicrobial Agents·Evangelos J Giamarellos-Bourboulis
Feb 19, 2008·International Journal of Antimicrobial Agents·Marie Tré-HardyMichel Jean Devleeschouwer
Aug 19, 2008·International Journal of Antimicrobial Agents·Evangelos J Giamarellos-Bourboulis
Feb 2, 2008·Biological & Pharmaceutical Bulletin·Daisei MiyamotoYasuo Suzuki

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
MDA
Assay

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

International Journal of Antimicrobial Agents
Evangelos J Giamarellos-BourboulisHelen Giamarellou
Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica
Ercole ConciaLEVT07 Study Group
The Annals of Pharmacotherapy
Carrie A Quigley, Janet R Lederman
© 2021 Meta ULC. All rights reserved