Clarithromycin versus amoxicillin-clavulanic acid in the treatment of community-acquired pneumonia

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
D GennéA de Torrenté

Abstract

In an open, prospective, randomised study, the clinical and bacteriological efficacy of intravenously administered clarithromycin was compared with that of amoxicillin-clavulanic acid in 112 patients with community-acquired pneumonia requiring hospitalisation. Clinical cure or improvement occurred in 86% (48/56) of the clarithromycin-treated patients and 84% (47/56) of the amoxicillin-clavulanic acid-treated patients. The rate of bacteriologic eradication was similar for the two drugs as were the rapidity of a clinical response and the rate of improvement of radiological signs. Clarithromycin had a slightly higher rate of side-effects mainly due to phlebitis caused by the intravenous treatment, but treatment could be continued in all cases. Clarithromycin should be used with caution in patients being treated with digoxin because of a significant risk of bradycardia resulting from drug interaction.

References

Nov 1, 1992·The Journal of Hospital Infection·R D Meyer, R G Finch
Oct 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G Kinasewitz, R G Wood
Dec 14, 1995·The New England Journal of Medicine·J G Bartlett, L M Mundy
Mar 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R BohteP J van den Broek
Jun 15, 1994·JAMA : the Journal of the American Medical Association·R F BreimanR R Facklam
Dec 29, 1995·The American Journal of Medicine·F Vogel

❮ Previous
Next ❯

Citations

Sep 28, 2001·International Journal of Antimicrobial Agents·L Mulazimoglu
Aug 7, 2003·The Lancet Infectious Diseases·Gavin D BarlowDilip Nathwani
Jan 26, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph P Lynch III, Fernando J Martinez
Dec 4, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Victor L YuMiguel Sabria
Nov 20, 2001·Thorax·UNKNOWN British Thoracic Society Standards of Care Committee
Jun 12, 2001·Drugs·J A Balfour, D P Figgitt
Apr 2, 2011·Indian Journal of Pharmacology·Abdulkadir KuçukbayrakEzgi Simsek
Oct 30, 2012·Journal of Clinical Anesthesia·Andrew T Ratcliffe, Khaled M Ismail
Jul 5, 2005·The American Journal of Medicine·Ronald F GrossmanJames S Tan
Feb 7, 2002·Expert Opinion on Investigational Drugs·Joseph M BlondeauGlen T Hansen
Nov 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D GennéD Lew
May 12, 2010·International Journal of Clinical Practice·T E AlbertsonM S Niederman
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Noa Eliakim-RazLeonard Leibovici
May 1, 1999·Postgraduate Medicine·R B Kohler
Sep 13, 2000·Drugs & Aging·D Lieberman, D Lieberman
Nov 19, 2019·Frontiers in Pharmacology·Yang LiuBirong Dong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.