Class I and class II regions of the major histocompatibility complex both contribute to individual odors in congenic inbred strains of rats

Behavior Genetics
R E BrownP B Singh

Abstract

The major histocompatibility complex (MHC) of the rat has three regions--A (class I), B/D (class II), and C/E (class I)--and congenic strains are available which differ in each of these regions. We used the habituation-dishabituation procedure to examine the ability of PVG-RT1u male rats to discriminate between the urinary odors of congenic rat strains which differ genetically only at certain individual regions of the MHC. The results of five experiments indicate that discrimination can be made between urine from rats which differ in all three regions of the MHC (PVG vs. PVG-RT1av1 donors), only in the class I A region (PVG vs. PVG.R1 donors), only in the class I C/E region (PVG.R19 vs. PVG-RT1av1 donors), only in the class II B/D region (PVG.R1 vs. PVG.R19 donors), and in all regions except the classical class IA locus (PVG-RT1av1 vs. PVG.R1 donors). These results indicate that all of the MHC regions may contribute to the individual odors of rats.

References

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Citations

May 1, 1990·Journal of Chemical Ecology·P B SinghR E Brown
Aug 1, 1995·International Journal of Immunopharmacology·R E Brown
Jul 31, 1998·Human Immunology·J C McDonald, I Adamashvili
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·K YamazakiE A Boyse
Jun 3, 1998·Proceedings. Biological Sciences·T RülickeC Wedekind
Dec 1, 1992·Scandinavian Journal of Immunology·R J Booth, K R Ashbridge
Sep 13, 2008·PLoS Genetics·Raphaëlle ChaixPeter Donnelly
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·S MontagH G Rammensee
Aug 4, 2010·Immunogenetics·Pablo Sandro Carvalho SantosAndreas Ziegler
Dec 16, 1998·Animal Behaviour·K H OlsÉnÅ Langefors
Sep 27, 2002·American Journal of Reproductive Immunology : AJRI·Andreas ZieglerBarbara Uchanska-Ziegler
Nov 29, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C Wedekind
Jan 1, 1997·DNA Sequence : the Journal of DNA Sequencing and Mapping·A Ziegler

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