PMID: 6397068Dec 1, 1984Paper

Class I antigens of the major histocompatibility complex on cytotrophoblast of the human placental basal plate

American Journal of Reproductive Immunology : AJRI
M WellsW P Faulk

Abstract

The lack of class I antigens of the major histocompatibility complex (MHC) on syncytiotrophoblast has been proposed as an explanation for the survival of the allogeneic fetus. These antigens, however, have recently been detected on nonvillous trophoblastic columns of the early human placenta. By using a combination of immunofluorescence techniques to identify trophoblast, we have studied transplantation antigens of the cytotrophoblastic shell present in the basal plate of normal full-term human placentae. With the use of two different monoclonal antibodies to a common determinant of HLA (clones W6/32 and 61D2), it was shown that this subset of trophoblast does express class 1 MHC antigens. However, while these cells reacted uniformly with W6/32, only rare reactivity with 61D2 was found. Reactivity of polyclonal antisera to beta 2-microglobulin correlated with that seen using W6/32. These results are similar to those recently observed in a subset of trophoblast of the amniochorion to which the term "metatrophoblast" has been given.

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Citations

Jan 1, 1993·Immunologic Research·I A RooneyJ P Atkinson
Jul 1, 1986·Journal of Reproductive Immunology·J R Head, S D Gaede
Jul 1, 1986·Journal of Reproductive Immunology·W D Billington, F J Burrows
May 1, 1987·Journal of Reproductive Immunology·J S HuntG W Wood
Oct 1, 1987·Journal of Reproductive Immunology·M WellsC S Holgate
Sep 1, 1990·Journal of Reproductive Immunology·J M Risk, P M Johnson
Jun 1, 1990·American Journal of Reproductive Immunology : AJRI·J S Hunt, B L Hsi
Jan 1, 1990·American Journal of Reproductive Immunology : AJRI·J A LataJ B Smith
Nov 1, 1984·Annales d'immunologie·W Page Faulk
Sep 1, 1989·American Journal of Reproductive Immunology : AJRI·C A LabarrereO H Althabe
Nov 1, 1989·American Journal of Reproductive Immunology : AJRI·W P Faulk, J S Hunt
Mar 1, 1989·American Journal of Reproductive Immunology : AJRI·J Szekeres-BarthoM Paál
Sep 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·J N Bulmer
Nov 1, 1989·American Journal of Reproductive Immunology : AJRI·C A Labarrere
Apr 24, 2019·Advanced Pharmaceutical Bulletin·Elnaz MosaferiBehzad Baradaran
Apr 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joan S HuntCarole Ober
Feb 9, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Peter ParhamLisbeth A Guethlein
Nov 1, 1989·American Journal of Reproductive Immunology : AJRI·J S Hunt, J L Fishback
Nov 1, 1988·Histopathology·M Wells, J N Bulmer
Sep 1, 1986·American Journal of Reproductive Immunology and Microbiology : AJRIM·B L Hsi, C J Yeh

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