Oct 1, 1989

Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin. Overlap between class I cytotoxic T lymphocytes and antibody sites

The Journal of Experimental Medicine
M T SweetserT J Braciale

Abstract

The influenza hemagglutinin is a critical regulator of disease expression during influenza virus infection and serves as a major target for the host immune response to this pathogen. In this report, we have analyzed an immunodominant site on the hemagglutinin (residues 202-221) recognized by murine class I MHC-restricted T lymphocytes. This analysis has revealed evidence for the duplication of a T cell recognition site within the region 202-221. We have also identified critical amino acids necessary for class I-restricted T cell recognition within these two epitopes. In addition, we provide evidence that a site on the influenza hemagglutinin recognized by neutralizing antibody directly overlaps with an epitope recognized by class I MHC-restricted CTL.

Mentioned in this Paper

Immune Response
T-Lymphocyte
TC2 Cells
Hemagglutinins, Viral
Pathogenic Organism
Structure-Activity Relationship
Amino Acids, I.V. solution additive
Murine
Influenza virus vaccine
Antigenic Specificity

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