Class I major histocompatibility complex-restricted T lymphocyte recognition of the influenza hemagglutinin. Overlap between class I cytotoxic T lymphocytes and antibody sites.

The Journal of Experimental Medicine
M T SweetserT J Braciale

Abstract

The influenza hemagglutinin is a critical regulator of disease expression during influenza virus infection and serves as a major target for the host immune response to this pathogen. In this report, we have analyzed an immunodominant site on the hemagglutinin (residues 202-221) recognized by murine class I MHC-restricted T lymphocytes. This analysis has revealed evidence for the duplication of a T cell recognition site within the region 202-221. We have also identified critical amino acids necessary for class I-restricted T cell recognition within these two epitopes. In addition, we provide evidence that a site on the influenza hemagglutinin recognized by neutralizing antibody directly overlaps with an epitope recognized by class I MHC-restricted CTL.

References

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Citations

Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ming-Wei ChenChi-Huey Wong
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S HahnC M Rice
Jan 1, 2010·Viruses·Rogier BodewesGuus F Rimmelzwaan
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher W LawrenceThomas J Braciale

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