Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor.

The Journal of Biological Chemistry
Claudie LemercierSaadi Khochbin

Abstract

BCL6 is a member of the POZ/zinc finger (POK) family involved in survival and/or differentiation of a number of cell types and in B cell lymphoma upon chromosomal alteration. Transcriptional repression by BCL6 is thought to be achieved in part by recruiting a repressor complex containing two class I histone deacetylases (HDACs). In this study we investigated whether BCL6 could also target members of class II HDACs. Our results indicate that three related class II deacetylases, HDAC4, HDAC5, and HDAC7 can associate with BCL6 in vivo and in vitro. Using electron microscopy, we found that endogenous BCL6 and class II HDACs partially co-localize in the nucleus. Overexpression experiments showed that BCL6 and HDAC4, -5, or -7 are intermingled onto common nuclear substructures and form stable complexes. A highly conserved domain in the N-terminal region of HDAC5 and HDAC7 as well as the zinc finger region of BCL6 were found necessary for the complex formation in vivo and in vitro. Moreover, our data point to the zinc finger region of BCL6 as a multifunctional domain which, beside its known capacity to bind DNA, is involved in the nuclear targeting of the protein and in the recruitment of the class II HDACs, and hence constitutes an a...Continue Reading

References

Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·C C ChangR Dalla-Favera
Nov 1, 1996·Biochemical and Biophysical Research Communications·T YoshidaT Tokuhisa
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·S H HongM L Privalsky
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·M H KokenA Zelent
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·P DhordainD Leprince
Jan 28, 1999·Differentiation; Research in Biological Diversity·O Albagli-CurielC Pinset
Mar 19, 1999·Biochemical and Biophysical Research Communications·M NumotoJ Koshi
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M GrozingerS L Schreiber
Sep 16, 1999·The EMBO Journal·D B SparrowT J Mohun
Sep 16, 1999·The EMBO Journal·E A MiskaT Kouzarides
Oct 19, 1999·Molecular and Cellular Biology·A H WangX J Yang
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·X ZhouP A Marks
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·J LuE N Olson
Apr 5, 2000·The Journal of Biological Chemistry·C LemercierS Khochbin
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·C M Grozinger, S L Schreiber
Aug 25, 2000·Molecular and Cellular Biology·A H WangX J Yang
Oct 25, 2000·Molecular and Cellular Biology·O AlbagliF Puvion-Dutilleul
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·T A McKinseyE N Olson
Mar 16, 2001·Current Opinion in Genetics & Development·S KhochbinD Seigneurin-Berny
Aug 16, 2001·Nucleic Acids Research·E A MiskaT Kouzarides
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·X ZhouV M Richon
Oct 26, 2001·The Journal of Biological Chemistry·Hung-Ying KaoRonald M Evans
Dec 1, 2001·The Journal of Biological Chemistry·Amaris R Guardiola, Tso-Pang Yao
Dec 12, 2001·The Journal of Biological Chemistry·Denise D FischerDalia Cohen

❮ Previous
Next ❯

Citations

Feb 7, 2008·Cell Biochemistry and Biophysics·Kathryn J Brayer, David J Segal
Jun 11, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Maribel CottoEileen Pacheco
Feb 13, 2004·Gene·Boris Bartholdy, Patrick Matthias
May 7, 2013·Trends in Immunology·Guideng LiPaolo Casali
Apr 25, 2003·Trends in Genetics : TIG·Eric VerdinHerbert G Kasler
Feb 16, 2005·Nature Neuroscience·Alexandre MéjatLaurent Schaeffer
Oct 27, 2009·Nature Reviews. Drug Discovery·Liqing WangWayne W Hancock
Aug 19, 2007·Oncogene·M A Glozak, E Seto
Aug 19, 2007·Oncogene·M MartinF Dequiedt
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sukhinder K SandhuCarlo M Croce
Apr 13, 2004·Molecular Biology of the Cell·Gabriela ParoniClaudio Brancolini
Nov 11, 2005·Molecular Biology of the Cell·Fang LiuGary D Kao
Feb 8, 2008·International Immunology·Kyoko OchiaiKazuhiko Igarashi
Apr 3, 2004·Nucleic Acids Research·Audrey CastetVincent Cavaillès
Nov 26, 2010·Genes & Development·Grant D BarishRonald M Evans
Sep 18, 2004·European Journal of Biochemistry·Tony LefebvreDominique Leprince
Jul 1, 2009·Molecular and Cellular Biology·Fang WeiMichael L Atchison
Sep 1, 2006·Molecular and Cellular Biology·Micah D GearhartVivian J Bardwell
Jan 24, 2008·Molecular and Cellular Biology·Lourdes M MendezB Hilda Ye
Mar 31, 2005·Molecular and Cellular Biology·Xiang-Jiao Yang, Serge Grégoire
Jul 19, 2012·Biochemistry. Biokhimii︠a︡·S V RazinO L Kantidze
Oct 29, 2013·Haematologica·Emilie MamessierBertrand Nadel
Oct 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sara S HookRobert N Eisenman
Feb 13, 2016·Chonnam Medical Journal·Somy Yoon, Gwang Hyeon Eom
Apr 24, 2012·Hematology/oncology Clinics of North America·Jasmine Zain
Dec 24, 2015·Frontiers in Immunology·Hong Zan, Paolo Casali
Mar 12, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ciro MercurioPier Giuseppe Pelicci
Apr 7, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lucia Altucci, Saverio Minucci
Apr 7, 2009·Cancer Letters·Oronza Antonietta BotrugnoSaverio Minucci
Aug 5, 2008·Biochemical and Biophysical Research Communications·Yulei ShenWing C Chan
Jul 22, 2014·International Journal of Cancer. Journal International Du Cancer·René ScholtysikRalf Küppers
Aug 24, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Nobuhiro SasaiMasashi Kawaichi
Jun 18, 2003·Microscopy Research and Technique·Francine Puvion-DutilleulOlivier Albagli-Curiel
Sep 17, 2005·Journal of Cellular Biochemistry·Bryan E LinggiScott W Hiebert
Apr 17, 2012·Immunological Reviews·Katia Basso, Riccardo Dalla-Favera
Jan 3, 2013·Immunology·Taku Naito, Ichiro Taniuchi
Jun 26, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Z WeiY Tian
Mar 4, 2014·Epigenomics·Zhengke WangTing C Zhao
Sep 26, 2006·Trends in Cell Biology·Kevin F Kelly, Juliet M Daniel

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.