Class II Human Leukocyte Antigen Epitope Mismatch Predicts De Novo Donor-Specific Antibody Formation After Liver Transplantation.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Chandrashekhar A KubalAndrew Lobashevsky

Abstract

Formation of de novo donor-specific antibodies (dn-DSAs) has been associated with longterm immunologic complications after liver transplantation (LT). We hypothesized that human leukocyte antigen (HLA) epitope/eplet mismatch (MM) is a marker of immunogenicity and a risk factor for dn-DSA formation. Sera from 80 LT recipients were prospectively screened for dn-DSA by a Luminex single-antigen test (One Lambda, Inc., Canoga Park, CA) at 1, 2, 3, 6, 12, 18, 24, and 36 months after LT. HLA typing of the recipients and donors was performed using polymerase chain reaction (PCR)-SSP and PCR-SSOP Luminex low-resolution methods (One Lambda, Inc.). The HLAMatchmaker computer algorithm was used for identification of MM eplets at HLA-DRB1 and -DQA1/B1 loci. Luminex single-antigen bead solid phase assay was used for antibody analysis. Standard immunosuppression included thymoglobulin-rituximab induction and tacrolimus maintenance. There were 27 (34%) patients who developed dn-DSA. There were no episodes of antibody-mediated rejection, and 9 (11%) developed acute cellular rejection (ACR). A positive crossmatch status and a higher number of HLA-A, -B, -DR, and -ABDR MMs were not associated with dn-DSA formation. Patients developing dn-DSA had ...Continue Reading

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Citations

Oct 18, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Magdalena MeszarosJérôme Dumortier
Nov 6, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Magdalena MeszarosGeorges-Philippe Pageaux
Sep 29, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Annette M JacksonSandy Feng
Nov 11, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Robin SchmitzJean Kwun
Jun 4, 2020·Annals of Gastroenterological Surgery·Masahiro OhiraHideki Ohdan
Dec 8, 2019·Gastroenterología y hepatología·Julien VionnetJordi Colmenero
Jul 27, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kosuke OnoHideki Ohdan
Dec 5, 2021·HLA : Immune Response Genetics·Estelle GeffardNicolas Vince

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