Class II major histocompatibility complex transactivator (CIITA) inhibits matrix metalloproteinase-9 gene expression.

The Journal of Biological Chemistry
Susan NozellEtty N Benveniste

Abstract

Matrix metalloproteinases (MMPs) are a family of structurally related proteins with the collective capability to degrade all components of the extracellular matrix. Although MMP-mediated degradation of the extracellular matrix occurs physiologically, numerous pathological conditions exhibit increased MMP levels and excessive matrix degradation. Previous work from our laboratory has shown that interferon-gamma inhibits MMP-9 expression in a manner dependent upon STAT-1alpha. Here we extend our previous observations and show that the class II major histocompatibility complex transactivator (CIITA), a transcriptional target of STAT-1alpha, is also capable of inhibiting MMP-9 expression. By using stable cell lines that inducibly express CIITA or various mutant forms of CIITA, we show that CIITA requires the ability to bind the CREB-binding protein (CBP) to effectively inhibit MMP-9 expression. Furthermore, we show that CIITA-mediated inhibition of the MMP-9 gene does not rely on the transcriptional capability of CIITA. These findings support a model wherein CIITA inhibits MMP-9 expression by binding to and sequestering CBP, which reduces the levels of CBP at the MMP-9 promoter, inhibits levels of acetylated histone 3 at the MMP-9 p...Continue Reading

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R McKendryG R Stark
Sep 1, 1980·European Journal of Biochemistry·J BodeE Wingender
Jan 1, 1996·Critical Reviews in Immunology·W M RohnE N Benveniste
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T J SiskC H Chang
Nov 10, 2000·Biochemical and Biophysical Research Communications·A Mori-AokiK Suzuki
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T S Gourley, C H Chang
Mar 14, 2001·Trends in Biochemical Sciences·S Smith
Mar 15, 2001·Current Opinion in Cell Biology·J N Ihle
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y DongE N Benveniste
Aug 11, 2001·Science·T Jenuwein, C D Allis
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z MaE N Benveniste
May 2, 2002·Cell·Jenny Pan-Yun Ting, John Trowsdale
May 3, 2002·The Journal of Biological Chemistry·Pritam K SenguptaBarbara D Smith
Jan 24, 2003·Critical Reviews in Biochemistry and Molecular Biology·Philippe E Van den SteenGhislain Opdenakker
Jun 13, 2003·Genome Biology·Robert P T SomervilleSuneel S Apte
Jul 8, 2003·The Journal of Pathology·Ivan Stamenkovic
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina S K YeeCheong-Hee Chang

❮ Previous
Next ❯

Citations

Mar 29, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Travis LaverEtty N Benveniste
Jan 24, 2009·Biology of Reproduction·Shawn P MurphyB Anne Croy
Oct 24, 2008·Journal of Virology·Klas StrååtCecilia Söderberg-Nauclér
Sep 10, 2008·Molecular and Cellular Biology·Susan NozellEtty N Benveniste
Aug 14, 2010·American Journal of Respiratory Cell and Molecular Biology·Yong XuBarbara D Smith
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Giovanna TosiRoberto S Accolla
Mar 21, 2013·Molecular Immunology·Gilberto Vargas-AlarcónJosé Manuel Fragoso
Oct 2, 2012·Archivos de cardiología de México·Hilda DelgadilloJosé Manuel Fragoso
Mar 30, 2010·Atherosclerosis·Smriti M KrishnaJonathan Golledge
Dec 2, 2008·Journal of Molecular and Cellular Cardiology·Xiaocen KongYong Xu
Dec 15, 2006·Journal of Cellular Physiology·Chunhong Yan, Douglas D Boyd
Oct 18, 2006·Journal of Korean Medical Science·Tae Woon KimKyeong Cheon Jung
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susan NozellEtty N Benveniste
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hao H HoLionel B Ivashkiv
Jun 21, 2005·The Journal of Biological Chemistry·Audrey H WangXiang-Jiao Yang
Jan 25, 2017·BioMed Research International·Ha Won Kim, Brian K Stansfield
May 8, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily ChiuDrew E Cressman

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.