Class IIa HDAC Downregulation Contributes to Surgery-Induced Cognitive Impairment Through HMGB1-Mediated Inflammatory Response in the Hippocampi of Aged Mice.

Journal of Inflammation Research
Chen-Miao HuangJun Li

Abstract

Perioperative neurocognitive disorders (PND) are a common complication in the elderly. Histone deacetylases (HDACs) are a class of enzymes that control the acetylation status of intracellular proteins. Thus, we explored whether HDACs trigger the release of high mobility group box 1 (HMGB1) through altering the acetylation status in the hippocampi of aged mice. The effect of the Class IIa HDAC in PND was explored using an in vivo form of splenectomy. Sixteen-month-old healthy male C57BL/6J mice were randomly divided into five groups: control, anesthesia plus sham surgery, anesthesia plus splenectomy, LMK235 treatment, and PBS treatment. The hippocampi were harvested on either first, third, or seventh postoperative day. Cognitive function was assessed via a Morris water maze (MWM) test. Quantitative RT-PCR, Western blots and ELISAs were carried out to assess the targeted gene expression at transcriptional and translational levels. Splenectomy led to a significant deficiency in spatial memory acquisition, marked decreases in mRNA and protein levels of HDAC4 and HDAC5 in the hippocampus, and increases in the levels of total HMGB1 and acetylated HMGB1. In a similar fashion to splenectomy, treatment with the HDAC4/5 inhibitor LMK235 ...Continue Reading

References

Sep 1, 1993·Journal of Neuroimmunology·E G GutierrezA J Kastin
Aug 18, 2001·Molecular and Cellular Biology·T A McKinseyE N Olson
Dec 18, 2002·The EMBO Journal·Tiziana BonaldiMarco E Bianchi
Apr 2, 2005·Nature Reviews. Immunology·Michael T Lotze, Kevin J Tracey
Dec 1, 2006·Human Reproduction Update·Andrea Riccardo GenazzaniMichele Luisi
Feb 24, 2011·Acta Anaesthesiologica Scandinavica·G WuriS-N Zhu
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mi-Sung KimLisa M Monteggia
Aug 24, 2012·Journal of Alzheimer's Disease : JAD·Roberto Carlos Agis-BalboaAndre Fischer
Oct 23, 2013·Neuroscience Research·Monty LymanDaqing Ma
Mar 17, 2015·Neuroscience·R M BarrientosS F Maier
Mar 18, 2015·Experimental and Therapeutic Medicine·Dong XiaoXuezhong Xing
Dec 31, 2015·Antioxidants & Redox Signaling·Ben LuKevin J Tracey
Jul 29, 2016·Human Molecular Genetics·Stefania TrazziElisabetta Ciani
Nov 9, 2016·Frontiers in Immunology·Niccolò TerrandoJianbin Tong
Feb 27, 2017·Ageing Research Reviews·Mahban RahimifardSeyed Fazel Nabavi
Nov 22, 2017·British Journal of Anaesthesia·M J NeedhamD C Bryden
Feb 16, 2018·Expert Opinion on Therapeutic Targets·Ulf AnderssonHelena Harris
Feb 27, 2018·Journal of Innate Immunity·Hannah AucottHelena Erlandsson Harris
Mar 14, 2018·Seminars in Immunology·Ulf AnderssonHelena Harris
Oct 24, 2018·EBioMedicine·Azeem AlamDaqing Ma
Nov 1, 2018·American Journal of Physiology. Renal Physiology·Siwei WeiZhongqing Chen
Apr 23, 2019·Psychiatria polska·Katarzyna Czyż-SzypenbejlKatarzyna Lewandowska

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