Class side effects: decreased pressure in the lower oesophageal and the pyloric sphincters after the administration of dopamine antagonists, neuroleptics, anti-emetics, L-NAME, pentadecapeptide BPC 157 and L-arginine

Inflammopharmacology
Z Belosic HalleP Sikirić

Abstract

The ulcerogenic potential of dopamine antagonists and L-NAME in rats provides unresolved issues of anti-emetic neuroleptic application in both patients and experimental studies. Therefore, in a 1-week study, we examined the pressures within the lower oesophageal and the pyloric sphincters in rats [assessed manometrically (cm H2O)] after dopamine neuroleptics/prokinetics, L-NAME, L-arginine and stable gastric pentadecapeptide BPC 157 were administered alone and/or in combination. Medication (/kg) was given once daily intraperitoneally throughout the 7 days, with the last dose at 24 h before pressure assessment. Given as individual agents to healthy rats, all dopamine antagonists (central [haloperidol (6.25 mg, 16 mg, 25 mg), fluphenazine (5 mg), levomepromazine (50 mg), chlorpromazine (10 mg), quetiapine (10 mg), olanzapine (5 mg), clozapine (100 mg), sulpiride (160 mg), metoclopramide (25 mg)) and peripheral(domperidone (10 mg)], L-NAME (5 mg) and L-arginine (100 mg) decreased the pressure within both sphincters. As a common effect, this decreased pressure was rescued, dose-dependently, by BPC 157 (10 µg, 10 ng) (also note that L-arginine and L-NAME given together antagonized each other's responses). With haloperidol, L-NAME wo...Continue Reading

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Citations

Jan 10, 2019·World Journal of Gastroenterology : WJG·Domagoj DrmicPredrag Sikiric
Jun 18, 2020·World Journal of Hepatology·Marijan KolovratPredrag Sikiric
Apr 1, 2020·World Journal of Gastrointestinal Pathophysiology·Slaven GojkovicPredrag Sikiric
Jun 29, 2021·Frontiers in Pharmacology·Mirna ZlatarPredrag Sikiric
Jul 17, 2021·Frontiers in Pharmacology·Sven SeiwerthPredrag Sikiric
Aug 13, 2021·Neural Regeneration Research·Jakša VukojevicPredrag Sikirić

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