Class-specific effects of selenium on PWM-driven human antibody synthesis in vitro

Biological Trace Element Research
U ReinholdP Wernet

Abstract

The influence of inorganic and organic forms of selenium (Se) on human antibody production was studied in a Pokeweed Mitogen (PWM)-driven in vitro system. Mitogen-stimulated peripheral blood mononuclear cells (PBMC) of eight healthy donors were cultured with different Se compounds at concentrations between 10(-3) and 10(-9) M. At high Se levels (10(-3)-10(-4) M), IgM and IgG production of all donors were strongly inhibited owing to reduced cell viability. However, in five of eight donors, low levels of Se enhanced IgG secretion. This was most effective in the presence of inorganic Se, whereas selenomethionine and selenocystine were less effective. In contrast to IgG, IgM synthesis was significantly reduced by low Se levels in five donors. No significant correlation between donor serum Se levels and antibody production in vitro was found. The addition of low levels of Se to PBMC, stimulated with PHA or PWM, showed no effect on proliferation, whereas a high concentration (5 x 10(-3) M) of sodium selenite and selenocystine suppressed proliferation owing to reduced cell viability. Thus, the present results show that Se supplementation can enhance human antibody production and, moreover, suggest some selectivity of Se action on huma...Continue Reading

References

Apr 1, 1978·Bioinorganic Chemistry·G N Schrauzer, D A White
Jan 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·J E SpallholzR H Heinzerling
Apr 1, 1986·Journal of Leukocyte Biology·R R WatsonD Lucas
Apr 1, 1987·Environmental Research·L Kiremidjian-Schumacher, G Stotzky
Jan 1, 1986·Advances in Experimental Medicine and Biology·C Ip
Dec 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·S A MulhernL E Magruder
Jan 1, 1985·Veterinary Immunology and Immunopathology·R J TurnerN F Beck
Jul 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·J E SpallholzR H Heinzerling
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Jul 16, 1983·Lancet·W C WillettC G Hames
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·W M Ching
Feb 1, 1983·The Journal of Nutrition·D Behne, W Wolters
Feb 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·J A MarshG F Combs
Dec 1, 1986·Biological Trace Element Research·H T PetrieH D Kay
Jan 1, 1987·Immunology Today·J M Teale, K M Abraham

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Citations

Jan 1, 1992·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·R D WangY Luo
Nov 30, 2007·Clinical Interventions in Aging·Tamas FülöpGraham Pawelec
Aug 1, 1993·Forensic Science International : Synergy·R LemkeW Makropoulos
Dec 31, 2020·Sports Medicine International Open·José Augusto Rodrigues SantosRodrigo Zacca

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