Class switch recombination in B lymphopoiesis: a potential pathway for B cell autoimmunity

Autoimmunity Reviews
Eran Diamant, Doron Melamed

Abstract

Pathogenic autoantibodies detected in autoimmune diseases are predominantly IgG isotypes, reflecting the generation and activation of an autoimmune memory B cell repertoire. It is not completely understood how such autoreactive cells are generated and escape central and/or peripheral tolerance mechanisms, and several models to explain this have been proposed. It is generally thought that B lymphocytes utilize IgM receptors for development and tolerance establishment, whereas IgG receptors are primarily used to promote memory formation and signal for memory-type responses. In here we review recent findings suggesting that spontaneously occurring class switch recombination in B lymphopoiesis confer B lymphocytes with a novel developmental pathway that is driven by non-IgM receptors. The physiological relevance of this developmental pathway in generating an autoimmune memory repertoire, as well as a Fas-dependent mechanism regulating it, is discussed.

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Citations

Jun 24, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S Ferrari-Lacraz, S Ferrari
Feb 28, 2013·Hämostaseologie·M SchallerJ A Kremer Hovinga
May 15, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Efrat Edry, Doron Melamed
Nov 10, 2020·Hepatology Communications·Craig LammertNaga Chalasani

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