Classic and Novel Adipocytokines at the Intersection of Obesity and Cancer: Diagnostic and Therapeutic Strategies

Current Obesity Reports
Nikolaos SpyrouMaria Dalamaga

Abstract

In this review, we investigate the role of classic and novel adipocytokines in cancer pathogenesis synopsizing the mechanisms underlying the association between adipocytokines and malignancy. Special emphasis is given on novel adipocytokines as new evidence is emerging regarding their entanglement in neoplastic development. Recent data have emphasized the role of the triad of overweight/obesity, insulin resistance and adipocytokines in cancer. In the setting of obesity, classic and novel adipocytokines present independent and joint effects on activation of major intracellular signaling pathways implicated in cell proliferation, expansion, survival, adhesion, invasion, and metastasis. Until now, more than 15 adipocytokines have been associated with cancer, and this list continues to expand. While the plethora of circulating pro-inflammatory adipocytokines, such as leptin, resistin, extracellular nicotinamide phosphoribosyl transferase, and chemerin are elevated in malignancies, some adipocytokines such as adiponectin and omentin-1 are generally decreased in cancers and are considered protective against carcinogenesis. Elucidating the intertwining of inflammation, cellular bioenergetics, and adiposopathy is significant for the de...Continue Reading

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J M ZarlingG J Todaro
Dec 15, 1985·The Biochemical Journal·A Franzén, D Heinegård
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
Feb 24, 2001·Nature·C M SteppanM A Lazar
May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·C WeyerP A Tataranni
Jan 10, 2003·Clinical Endocrinology·M L DelporteM Lambert
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Eleni PetridouDimitrios Trichopoulos
Apr 25, 2003·The New England Journal of Medicine·Eugenia E CalleMichael J Thun
Oct 8, 2003·The Journal of Experimental Medicine·Valérie WittamerDavid Communi
May 13, 2004·British Journal of Cancer·S R Rittling, A F Chambers
Dec 14, 2004·European Journal of Endocrinology·Christos MantzorosDimitrios Trichopoulos
Jan 20, 2005·Journal of Internal Medicine·M E Trujillo, P E Scherer
Jan 29, 2005·Endocrinology·Jérémie BoucherPhilippe Valet
May 18, 2005·Endocrine Reviews·Takashi Kadowaki, Toshimasa Yamauchi
Jun 1, 2005·Urology·Serdar GoktasSelahattin Bedir
Jul 16, 2005·Cancer Letters·Da-Chung ChenShyng-Shou F Yuan
Jul 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kazuyuki HidaYashpal S Kanwar
Jan 13, 2006·Trends in Cell Biology·Hema RangaswamiGopal C Kundu
Feb 2, 2006·The Journal of Clinical Endocrinology and Metabolism·Dominik G HaiderBernhard Ludvik
Mar 15, 2006·American Journal of Physiology. Endocrinology and Metabolism·Rong-Ze YangDa-Wei Gong
Mar 30, 2006·British Journal of Cancer·I KelesidisC S Mantzoros
Jan 11, 2007·The Journal of Clinical Endocrinology and Metabolism·Shelley S TworogerSusan E Hankinson
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander R MoschenHerbert Tilg
Apr 20, 2007·International Journal of Cancer. Journal International Du Cancer·Susanna C Larsson, Alicja Wolk
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lígia R RodriguesHelena Lindmark-Mänsson
Jul 20, 2007·The Journal of Biological Chemistry·Kerry B GoralskiChristopher J Sinal
Jul 21, 2007·Endocrinology·Kiymet BozaogluDavid Segal
Jul 31, 2007·Journal of Clinical Pathology·Mariusz KodaStanislaw Sulkowski
Nov 22, 2007·International Journal of Cancer. Journal International Du Cancer·Susanna C Larsson, Alicja Wolk
Feb 13, 2008·The American Journal of Clinical Nutrition·Diana BarbChristos S Mantzoros
Mar 7, 2008·Expert Opinion on Investigational Drugs·Jun Wada

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Citations

Mar 27, 2019·Medicina·Marcin TrojnarBożena Leszczyńska-Gorzelak
Oct 23, 2019·Current Obesity Reports·Gerasimos Socrates ChristodoulatosMaria Dalamaga
Feb 25, 2020·PloS One·David J FerlandStephanie W Watts
Jun 21, 2020·International Journal of Environmental Research and Public Health·Anna CzajkowskaŁukasz Małek
May 18, 2020·Current Obesity Reports·Kyriaki ParoutoglouMaria Dalamaga
Aug 30, 2020·Journal of Clinical Medicine·Adela-Viviana Sitar-TautAngela Cozma
Jul 18, 2020·International Journal of Molecular Sciences·Eunah Shin, Ja Seung Koo
Feb 20, 2020·International Journal of Molecular Sciences·Fionán DonohoeDonal J Brennan
Jan 5, 2020·Critical Reviews in Food Science and Nutrition·Oswaldo Pablo Martínez-RodríguezMaría Eugenia Jaramillo-Flores
Aug 28, 2020·Scientific Reports·Rosario Castro-OropezaVilma Maldonado
Feb 2, 2021·Current Obesity Reports·Georgia ArgyrakopoulouAlexander Kokkinos
Mar 11, 2021·International Journal of Endocrinology·Grigorios PanagiotouEleni Papakonstantinou
May 15, 2021·Seminars in Cancer Biology·Nikolaos SpyrouMaria Dalamaga
Jul 28, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Andrea G IzquierdoAna B Crujeiras

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