Classic chronic pancreatitis is associated with prior acute pancreatitis in only 50% of patients in a large single-institution study

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Yasuki HoriMark D Topazian

Abstract

The sentinel acute pancreatitis event (SAPE) hypothesis for pathogenesis of chronic pancreatitis (CP) postulates that acute pancreatitis (AP), especially recurrent AP (RAP), precedes development of CP. However, in a recent population-based study, 52/89 (58.4%) of CP had no prior episodes of AP. In a large clinic-based CP cohort, we aimed to determine the incidence and timing of prior AP in patients diagnosed with CP. We retrospectively identified 499 consecutive patients with classic CP diagnosed at our institution from January 2013 through December 2015. We abstracted their demographic and clinical data, especially regarding prior AP. We identified 3 cohorts: 1) CP with no AP (n = 231 [46.3%]), 2) AP before CP (n = 250 [50.1%]), and 3) AP after CP (n = 18 [3.6%]). At CP diagnosis, 249 patients (49.9%) had no prior AP. Compared with the "CP preceded by AP" cohort, the "CP without AP"' cohort was older (59.2 ± 13.9 vs 48.6 ± 15.7 years; P < .001), had a higher prevalence of diabetes mellitus (30.3% vs 12.4%; P < .001), reported less pain (52.8% vs 87.6%; P < .001), and had a lower rate of endoscopic interventions (16.0% vs 39.2%; P < .001). In the "CP preceded by AP" cohort, 117 (46.8%) had a single episode of AP and 133 (53.2%)...Continue Reading

Citations

Aug 23, 2019·PloS One·Naruomi JinnoKazuki Hayashi
Dec 21, 2019·JAMA : the Journal of the American Medical Association·Vikesh K SinghPramod K Garg
Mar 25, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Nan RuZhuan Liao
Apr 17, 2021·Scientific Reports·Yasuki HoriHirotaka Ohara
Aug 13, 2021·Respiratory Medicine Case Reports·Yasuki HoriHiromi Kataoka

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